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A multi-country assessment of societal resilience and preparedness during covid-19 times. A review among the coronadx horizon 2020 project

Background and Objective: The COVID-19 pandemic has led to complex challenges concerning the spreading of misinformation about origin, symptoms, and prevention of SARS-CoV-2. Unclear, changing, and variable guidelines confuse the public and plant seeds for misinformation. A wide range of strategies were used by leaders across many sectors to foster positive social norms and encourage people to protect their community and selves from COVID-19. The study provides an overview of communications i...

Identifying and scoping new options for healthcare system strengthening in North East Syria

Background and Objectives: Nowadays, North East Syria (NES) remains a complex humanitarian emergency, still bearing the devastating consequences of over a decade of ongoing hostilities that caused more than 400.000 deaths in Syria and led it to be the country with the worlds highest number of internally displaced persons (IDPs) until last year. NES security situation is still particularly fragile and highly dynamic, prone to escalations with the persistence of active armed clashes, airstrikes...

Pre-diagnostic prescribing patterns in dyspnoea patients with as-yet-undiagnosed lung cancer: A longitudinal study of linked primary care and cancer registry data

Introduction: Patients with as-yet undiagnosed lung cancer (LC) can present to primary care with non-specific symptoms such as dyspnoea, often in the context of pre-existing chronic obstructive pulmonary disease (COPD). Related medication prescriptions pre-diagnosis might represent opportunities for earlier diagnosis, but UK evidence is limited. Consequently, we explored prescribing patterns of relevant medications in patients who presented with dyspnoea in primary care and were subsequently ...

Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease

Missense mutations in the uromodulin (UMOD) gene cause autosomal dominant tubulointerstitial kidney disease (ADTKD), one of the most common monogenic kidney diseases. The unknown impact of the allelic and gene dosage effects and fate of mutant uromodulin leaves open the gap between postulated gain-of-function mutations, end-organ damage and disease progression in ADTKD. Based on two prevalent missense UMOD mutations with divergent disease progression, we generated Umod(C171Y) and Umod(R186S) ...

Vasostatin-1 as a potential novel circulating biomarker in patients with chronic systolic heart failure: A pilot study

Background and aims: Previous studies have shown that circulating chromogranin A (CgA) increases in patients with chronic systolic heart failure (HF). Aim of the present study is to evaluate the potential role of circulating vasostatin-1 (VS-1), a cardioregulatory fragment of CgA, as prognostic marker in patients with chronic HF. Materials and methods: The plasma levels of CgA and VS-1 were determined in 80 patients with chronic systolic HF. Patients were followed-up to evaluate the occurrenc...

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Prodotti recenti

A multi-country assessment of societal resilience and preparedness during covid-19 times. A review among the coronadx horizon 2020 project

Identifying and scoping new options for healthcare system strengthening in North East Syria

Pre-diagnostic prescribing patterns in dyspnoea patients with as-yet-undiagnosed lung cancer: A longitudinal study of linked primary care and cancer registry data

Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease

Vasostatin-1 as a potential novel circulating biomarker in patients with chronic systolic heart failure: A pilot study

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