The transduction of extracellular signals through adhesion and guidance receptors into cytoskeleton reorganization underlies axon outgrowth and pathfinding decisions. The cytoplasmic protein tyrosine kinase focal adhesion kinase (FAK), a central regulator of cell motility phenomena during morphogenesis, is highly expressed in the developing nervous system and selectively enriched in axonal growth cones. Novel studies implicate FAK in the control of neuronal migration and axon behavior during nervous system development. By scaffolding receptorproximal multiprotein complexes, FAK guarantees the integration of adhesive signals derived from the extracellular matrix with guidance cues and growth factors at the level of the developing axons. © 2007 Springer Science+Business Media, LLC.
Focal adhesion kinase in neuritogenesis / Bonanomi, D.; Valtorta, F.. - (2007), pp. 155-179. [10.1007/978-0-387-68561-8_7]
Focal adhesion kinase in neuritogenesis
Valtorta F.
Secondo
2007-01-01
Abstract
The transduction of extracellular signals through adhesion and guidance receptors into cytoskeleton reorganization underlies axon outgrowth and pathfinding decisions. The cytoplasmic protein tyrosine kinase focal adhesion kinase (FAK), a central regulator of cell motility phenomena during morphogenesis, is highly expressed in the developing nervous system and selectively enriched in axonal growth cones. Novel studies implicate FAK in the control of neuronal migration and axon behavior during nervous system development. By scaffolding receptorproximal multiprotein complexes, FAK guarantees the integration of adhesive signals derived from the extracellular matrix with guidance cues and growth factors at the level of the developing axons. © 2007 Springer Science+Business Media, LLC.File | Dimensione | Formato | |
---|---|---|---|
978-0-387-68561-8_7.pdf
solo gestori archivio
Tipologia:
PDF editoriale (versione pubblicata dall'editore)
Licenza:
Altra licenza
Dimensione
2.12 MB
Formato
Adobe PDF
|
2.12 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.