TROPION-Breast04: a randomized phase III study of neoadjuvant datopotamab deruxtecan (Dato-DXd) plus durvalumab followed by adjuvant durvalumab versus standard of care in patients with treatment-naïve early-stage triple negative or HR-low/HER2− breast cancer

Background: Despite treatment advances for patients with early-stage triple-negative breast cancer (TNBC) and hormone receptor (HR)-low/human epidermal growth factor receptor 2-negative (HER2−) breast cancer, treatments that improve clinical outcomes while mitigating toxicity are needed. Datopotamab deruxtecan (Dato-DXd), a TROP2-directed antibody-drug conjugate consisting of a humanized IgG1 monoclonal antibody attached via a plasma-stable cleavable linker to a topoisomerase-I inhibitor payl...

Commentary: The role of impact on the meaning of generic sentences

Ragionamento morale e intelligenza artificiale: potenzialità e limiti

The relationship between moral reasoning and artificial intelligence (AI) raises profound philosophical and normative questions. Can machines reason morally, or can they only simulate ethical judgment through computational processes? This article examines the potentials and limits of AI in relation to moral reasoning by distinguishing three levels of analysis: AI as a tool for human moral deliberation, AI as a potential moral agent, and AI as a meta-ethical challenge. Drawing on classical mor...

Jean-Paul Sartre. A 120 anni dalla nascita

This article reconstructs the philosophical itinerary of Jean-Paul Sartre on the occasion of the 120th anniversary of his birth, tracing the development of his thought from the early phenomenological works to the late political writings. It examines the central themes of radical freedom, bad faith, existentialist engagement, and the progressive-regressive method, showing how Sartre continuously renegotiated the relationship between individual subjectivity, history, and Marxism. Special attent...