A CREATE-Based Educational Intervention to Improve Evidence-Based Practice Competencies in a Low-Income Country: A Feasibility Pilot Study

Background: Evidence-based practice (EBP) competencies remain limited in many low-income countries, where access to research training is often constrained by limited educational resources and humanitarian crises. This study evaluated the feasibility and preliminary effectiveness of a CREATE-based teaching strategy to improve EBP competencies among nurses and nursing students in Sudan. Methods: A quasi-experimental pre–post study without a control group was conducted among 29 participants (17 ...

Pancreatectomy and Islet Autotransplantation for Intraductal Papillary Mucinous Neoplasms and Pancreatic Neoplasms

Total pancreatectomy with islet autotransplantation (TPIAT) has traditionally been employed for patients with chronic pancreatitis, but its use has increasingly expanded to include specific cases of pancreatic neoplasms. The Milan protocol has systematically extended TPIAT indications to both malignant and nonmalignant pancreatic lesions, provided that multifocality is excluded preoperatively and confirmed with negative intraoperative frozen section margins. This procedure is also being explo...

Essere agenti nell’età globale: implicazioni etiche e spunti per l’educazione scientifica

Inflammatory macrophages promote metastatic potential in Triple-negative Breast Cancer through Integrated Stress Response signaling

Triple-negative Breast Cancer (TNBC) is characterized by inflammatory myeloid infiltration and a high metastatic potential, however, the mechanisms by which macrophage-derived signals govern tumor cell plasticity remain poorly understood. Here, through patient transcriptomic analyses, in vitro functional studies, and in vivo metastasis models, we identify the Integrated Stress Response (ISR) as a critical tumor cell-intrinsic pathway that translates inflammatory macrophage-derived cues into m...