Towards safer colorectal surgery worldwide: Outcomes and benchmarks from the ESCP CORREA 2022 audit

Introduction: Benchmarking colorectal surgery outcomes informs quality improvement. The ESCP CORREA 2022 snapshot audit aimed to assess contemporary colorectal resection practices and short-term outcomes across European countries and beyond. Methods: An international prospective multicentre audit was conducted in which adults undergoing elective or emergency colorectal resection during a 6-week period (January–April 2022) at participating hospitals were included. Data on patient demographics,...

A year of impact: the best articles of 2024 in Signa Vitae

Safety and Efficacy of Tranexamic Acid in General Surgery

Importance: Perioperative bleeding is common in general surgery. The POISE-3 (Perioperative Ischemic Evaluation-3) trial demonstrated efficacy of prophylactic tranexamic acid (TXA) compared with placebo in preventing major bleeding without increasing vascular outcomes in noncardiac surgery. Objective: To determine the safety and efficacy of prophylactic TXA, specifically in general surgery. Design, Setting, and Participants: Subgroup analyses were conducted that compared randomized treatment ...

Longitudinal transcriptomic profiling identifies predictors of response to neoadjuvant chemoimmunotherapy in triple-negative breast cancer: results from the NeoTRIPaPDL1 trial

Background: Triple-negative breast cancer (TNBC) is immunogenic, but only a subset of patients benefits from neoadjuvant immune checkpoint inhibitors combined with chemotherapy. Predictive biomarkers to guide patient selection and treatment adaptation are lacking. Patients and methods: In the randomized phase III NeoTRIPaPDL1 trial, 280 patients with high-risk TNBC received neoadjuvant carboplatin plus nab-paclitaxel (CT, n = 142) or the same regimen with atezolizumab (CT/A, n = 138). Tumor b...