More than “hematology”: a qualitative study on the experience of hematologists treating people with blood cancer in Greece

Purpose: The present study aims to investigate the experiences of hematologists providing care to patients with hematological malignancies, whose care is pertinent to oncology. Methods: Semi-structured interviews with 30 hematologists across Greece were conducted. The interviews took place over the course of 6 months at 2020. Reflexive thematic analysis was employed for data analysis. Results: Three key themes (personal impact, organizational framework, and relating to patients) and eight sub...

Loss of CYLD promotes splenic marginal zone lymphoma

Splenic marginal zone lymphoma (SMZL) is a distinct clinical and pathological entity among marginal zone lymphomas. Genetic and microenvironmental factors leading to aberrant activation of the NF-κB pathway have been implicated in SMZL pathogenesis. CYLD is a negative regulator of NF-κB and other signaling pathways acting as a deubiquitinase of regulatory molecules and has been reported as a tumor suppressor in different types of cancer, including B-cell malignancies. To assess whether CYLD i...

Increasing Pancreatic Cancer Incidence in Young Women in the United States: A Population-Based Time-Trend Analysis, 2001-2018 - Reply

Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries

Background: This study assessed the potential cost-effectiveness of high (80e100%) vs low (21e35%) fraction of inspired oxygen (FiO2 ) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa. Methods: Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO2 , published literature, and a cost survey in Nigeria, India, and South Africa. ...