Post-entry events of efficient R5 vs. inefficient X4 HIV-1 replication in primary CD4+T lymphocytes, a transcriptome analysis

Nef-specific CD45RA+ CD8+ T cells secreting MIP-1β but not IFN-γ are associated with nonprogressive HIV-1 infection

Background: Long-term survival of HIV-1 infected individuals is usually achieved by continuous administration of combination antiretroviral therapy (ART). An exception to this scenario is represented by HIV-1 infected nonprogressors (NP) which maintain relatively high circulating CD4+ T cells without clinical symptoms for several years in the absence of ART. Several lines of evidence indicate an important role of the T-cell response in the modulation of HIV-1 infection during the acute and ch...

Restriction of Zika Virus Replication in Human Monocyte-Derived Macrophages by Pro-Inflammatory (M1) Polarization

Zika virus (ZIKV), a member of the Flaviviridae family, is primarily transmitted through mosquito bites, but can also spread via sexual contact and from mother to fetus. While often asymptomatic, ZIKV can lead to severe neurological conditions, including microcephaly in fetuses and Guillain–Barré Syndrome in adults. ZIKV can infect placental macrophages and fetal microglia in vivo as well as human monocytes and monocyte- derived macrophages (MDMs) in vitro. Here, we observed that both human m...

Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load (Nature, (2023), 620, 7976, (1025-1030), 10.1038/s41586-023-06370-4)

Correction to: Nature Published online 2 August 2023 In the version of the article originally published, the “Acknowledgements” section was missing the following funding statement: “This work was supported in part by IAVI funded by the United States Agency for International Development (USAID). The full list of IAVI donors is available at. The contents of this manuscript are the responsibility of the authors and do not necessarily reflect the views of USAID or the US Government”. This has now...