1 Contributo su Rivista

1 Contributo su Rivista: [37144] Home page macrotipologia

Sfoglia

1.1 Articolo in rivista 31928
1.1.1 Articolo in rivista - Review 541
1.1.2. Articolo in Rivista - Letter, Note 485
1.1.3. Articolo in Rivista - Editorial, Comment, Reply 906
1.1.4. Guidelines, Consensus 90
1.1.5. Erratum 87
1.2 Recensione in rivista 264
1.3 Scheda bibliografica 14
1.4 Nota a sentenza 0
1.5 Abstract in rivista 2819
1.6 Traduzione in rivista 10

Prodotti recenti

Clinical profiling and outcomes of viral myocarditis manifesting with ventricular arrhythmias

Aims: Clinical features and risk stratification of patients with viral myocarditis (VM) complicated by ventricular arrhythmias (VA) are incompletely understood. We aim to describe arrhythmia patterns and outcomes in patients with VM and early-onset VA. Methods and results: We present a single-centre study, enrolling patients with VM proven by endomyocardial biopsy, and evidence of VA within 24 h of hospitalization. The incidence of major adverse events (MAE), including all-cause death, severe...

Presymptomatic geographical distribution of ALS patients suggests the involvement of environmental factors in the disease pathogenesis

Background: Given that the pathogenetic process of ALS begins many years prior to its clinical onset, examining patients' residential histories may offer insights on the disease risk factors. Here, we analyzed the spatial distribution of a large ALS cohort in the 50 years preceding the disease onset. Methods: Data from the PARALS register were used. A spatial cluster analysis was performed at the time of disease onset and at 1-year intervals up to 50 years prior to that. Results: A ...

Calculated Maximal Volume Ventilation (cMVV) as a Marker of Early Respiratory Failure in Amyotrophic Lateral Sclerosis (ALS)

: Respiratory failure assessment is among the most debatable research topics in amyotrophic lateral sclerosis (ALS) clinical research due to the wide heterogeneity of its presentation. Among the different pulmonary function tests (PFTs), maximal voluntary ventilation (MVV) has shown potential utility as a diagnostic and monitoring marker, able to capture early respiratory modification in neuromuscular disorders. In the present study, we explored calculated MVV (cMVV) as a prognostic biomarker...

Unexpected frequency of the pathogenic AR CAG repeat expansion in the general population

: CAG repeat expansions in exon 1 of the AR gene on the X chromosome cause spinal and bulbar muscular atrophy, a male-specific progressive neuromuscular disorder associated with a variety of extra-neurological symptoms. The disease has a reported male prevalence of 1:30,303 or less, but the AR repeat expansion frequency is unknown. We established a pipeline, which combines the use of the ExpansionHunter tool and visual validation, to detect AR CAG expansion on whole-genome sequencing data, be...

The role of peripheral immunity in ALS: a population-based study

Background: Systemic inflammation has been proposed as a relevant mechanism in amyotrophic lateral sclerosis (ALS). Still, comprehensive data on ALS patients' innate and adaptive immune responses and their effect on the clinical phenotype are lacking. Here, we investigate systemic immunity in a population-based ALS cohort using readily available hematological indexes. Methods: We collected clinical data and the complete blood count (CBC) at diagnosis in ALS patients from the Piemonte and Vall...

Scopri

Accesso al fulltext

no fulltext34867
open1172
reserved1079
partially open21
embargoed5