Biomarkers for Sarcopenia: Predicting Muscle Mass and Function Decline Through GDF-15, FGF21, sRAGE, and Neurofilaments

Sarcopenia is a major public health concern that significantly impacts the quality of life, morbidity, and mortality among older adults. Given the complex mechanisms underlying its development, recent efforts to enhance diagnostic approaches have increasingly focused on utilizing multiple blood-based biomarkers for screening. Through a Delphi consensus involving biologists and physicians from various Italian universities, we identified a panel of key biomarkers: FGF21 and GDF15, both mitokine...

Glucose regulates miR-125b expression via AMP-activated protein kinase (AMPK)

Gamma knife radiosurgery as primary treatment for pineal tumors. Clinical, radiological, and survival evaluation with targeted analysis of prognostic factors in a single-center original series

Background: Pineal region tumors (PTs) are a heterogeneous group of lesions whose management strategy remains controversial. Available data highlight the importance of the initial presumptive diagnosis for a therapeutic strategy which may comprise surgery for intrinsic lesions and chemo/radiotherapy for germ cell tumors. Surgical treatment, however, has been traditionally burdened by the extremely high rates of neurological de cits and perioperative mortality, thus Gamma Knife radiosurgery (G...

The clinical relevance of immune peripheral status and its relation to neuroradiological findings in newly diagnosed glioblastomas.

Background: High-grade gliomas are the most frequent and deadliest type of primary brain tumors in adults; despite the significant advances in understanding tumor biology, life expectancy of these patients is still limited. The aim of our study was to analyse blood cells counts and ratios as systemic inflammatory markers in newly diagnosed glioblastoma, to correlate these data with the radiological parameters and to identify their role as prognostic factors. Materials and methods: A retrospe...