: CD4 + T cells play a critical role in antiviral humoral and cellular immune responses. We have previously reported that subcutaneous lymphocytic choriomeningitis virus (s.c. LCMV) infection is characterized by a stark compartmentalization of CD4 + T cells, leading to strong T H 1 polarization but virtually absent T follicular helper (T FH ) cells, a key driver of humoral immunity. Here, we investigated the mechanisms responsible for this impaired T FH differentiation. We found that T-bet + ...
The interrelationship between male sexual desire and erectile dysfunction (ED) has been scantly investigated. Thus, we aimed at investigating the prevalence of and the predictors of unrecognized low sexual desire/interest (uLSD/I) in a cohort of men with new onset ED. Complete data from 1509 men seeking for first medical help for ED between 2010 and 2021 were analysed. Comorbidities were scored with the Charlson Comorbidity Index (CCI). At entrance, all patients were asked to self-report LSD/...
Background: Palliative care is crucial for patients with life-threatening and serious diseases like cancer, addressing their physical, psychosocial, and spiritual needs. Haematological Malignancies (HMs) significantly contribute to global cancer cases, impacting both older adults and children. To meet the increasing demand for palliative care, electronic patient-reported outcome (ePRO) interventions have emerged, offering valuable insights into patient monitoring and treatment decision-makin...
Background: Healthcare practitioners use Clinical Decision Support Systems (CDSS) as an aid in the crucial task of clinical reasoning and decision making. Traditional CDSS are Online Repositories (OR) and Clinical Practice Guidelines (CPG). Recently, Large Language Models (LLMs) like ChatGPT have emerged as potential alternatives. They have proven to be powerful innovative tools, yet they are not devoid of worrisome risks. Objective: This study aims to explore how medical students utilize Cha...