The instant invention refers to an optical method to extrapolate cell membrane conductance by indirect measurement of changes in transmembrane voltage upon exposure of at least a cell to electric field pulses, and to its application for evaluating the activity of molecules able to alter, directly or indirectly, membrane permeability. A specific field of application is the screening of candidate compounds, based on their effects on ion channel activity
METHOD FOR OPTICAL MEASURING VARIATIONS OF CELL MEMBRANE CONDUCTANCE
GROHOVAZ , FABIO;
2010-01-01
Abstract
The instant invention refers to an optical method to extrapolate cell membrane conductance by indirect measurement of changes in transmembrane voltage upon exposure of at least a cell to electric field pulses, and to its application for evaluating the activity of molecules able to alter, directly or indirectly, membrane permeability. A specific field of application is the screening of candidate compounds, based on their effects on ion channel activityFile in questo prodotto:
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