Background: Early-onset multiple sclerosis (MS) typically has a more favorable course than adult-onset disease. Objective: To assess the extent of microscopic tissue damage in the brain and cervical cord of patients with early-onset MS. Design: During a single magnetic resonance imaging session, images of the brain and spinal cord were obtained using diffusion tensor and magnetization transfer magnetic resonance imaging. Patients: We studied 13 patients with early-onset MS and 10 healthy volunteers. Results: Compared with control subjects, patients with early-onset MS showed only a slight increase of the average mean diffusivity of the normal-appearing brain tissue. Conclusion: The relatively modest central nervous system damage detected in these patients might explain why early-onset MS typically has a more favorable clinical course than adult-onset MS.

A preliminary diffusion tensor and magnetization transfer magnetic resonance imaging study of early-onset multiple sclerosis

Rocca MA;FALINI , ANDREA;COMI , GIANCARLO;FILIPPI , MASSIMO
2004-01-01

Abstract

Background: Early-onset multiple sclerosis (MS) typically has a more favorable course than adult-onset disease. Objective: To assess the extent of microscopic tissue damage in the brain and cervical cord of patients with early-onset MS. Design: During a single magnetic resonance imaging session, images of the brain and spinal cord were obtained using diffusion tensor and magnetization transfer magnetic resonance imaging. Patients: We studied 13 patients with early-onset MS and 10 healthy volunteers. Results: Compared with control subjects, patients with early-onset MS showed only a slight increase of the average mean diffusivity of the normal-appearing brain tissue. Conclusion: The relatively modest central nervous system damage detected in these patients might explain why early-onset MS typically has a more favorable clinical course than adult-onset MS.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/10339
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