Noninvasive assessment of corpus atrophic gastritis (CAG), a condition at increased risk of gastric cancer, is based on the measurement of pepsinogens, gastrin, and Helicobacter pylori antibodies. Parietal cell autoantibodies (PCAs) against the gastric proton pump (ATP4) are potential serological biomarkers of CAG. The purpose of this study was to compare the diagnostic performance of PCA and pepsinogen I tests in patients with clinical suspicion of CAG with the histopathological evaluation of gastric biopsies as reference standard.
Autoantibodies Toward ATP4A and ATP4B Subunits of Gastric Proton Pump H+,K+-ATPase Are Reliable Serological Pre-endoscopic Markers of Corpus Atrophic Gastritis / Lahner, Edith; Marzinotto, Ilaria; Lampasona, Vito; Dottori, Ludovica; Bazzigaluppi, Elena; Brigatti, Cristina; Secchi, Massimiliano; Piemonti, Lorenzo; Conti, Laura; Pilozzi, Emanuela; Davidson, Howard W; Wenzlau, Janet M; Annibale, Bruno. - In: CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY. - ISSN 2155-384X. - 11:10(2020), p. e00240. [10.14309/ctg.0000000000000240]
Autoantibodies Toward ATP4A and ATP4B Subunits of Gastric Proton Pump H+,K+-ATPase Are Reliable Serological Pre-endoscopic Markers of Corpus Atrophic Gastritis
Marzinotto, Ilaria;Piemonti, Lorenzo;
2020-01-01
Abstract
Noninvasive assessment of corpus atrophic gastritis (CAG), a condition at increased risk of gastric cancer, is based on the measurement of pepsinogens, gastrin, and Helicobacter pylori antibodies. Parietal cell autoantibodies (PCAs) against the gastric proton pump (ATP4) are potential serological biomarkers of CAG. The purpose of this study was to compare the diagnostic performance of PCA and pepsinogen I tests in patients with clinical suspicion of CAG with the histopathological evaluation of gastric biopsies as reference standard.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
