Immune reconstitution plays a crucial role on the outcome of patients given T cell-depleted HLA-haploidentical hematopoietic stem cell transplantation (hHSCT) for hematological malignancies. CD1d-restricted invariant NKT (iNKT) cells are innate-like, lipidreactive T lymphocytes controlling infections, cancer, and autoimmunity. Adult mature iNKT cells are divided in two functionally distinct CD4+ and CD4- subsets that express the NK receptor CD161 and derive from thymic CD4+CD1612 precursors. We investigated iNKT cell reconstitution dynamics in 33 pediatric patients given hHSCT for hematological malignancies, with a follow-up reaching 6 y posttransplantation, and correlated their emergence with disease relapse. iNKT cells fully reconstitute and rapidly convert into IFN-γ-expressing effectors in the 25 patients maintaining remission. CD4+ cells emerge earlier than the CD4- ones, both displaying CD1612 immature phenotypes. CD4- cells expand more slowly than CD4+ cells, though they mature with significantly faster kinetics, reaching full maturation by 18 mo post-hHSCT. Between 4 and 6 y post-hHSCT, mature CD4- iNKT cells undergo a substantial expansion burst, resulting in a CD4 +
Invariant NKT cell reconstitution in pediatric leukemia patients given HLA-haploidentical stem cell transplantation defines distinct CD4+ and CD4-subset dynamics and correlates with remission state / De Lalla, C., Rinaldi, A., Montagna, D., Azzimonti, L., Bernardo, M.E., Sangalli, L.M., Paganoni, A.M., Maccario, R., Cesare-Merlone, A.D., Zecca, M., Locatelli, F., Dellabona, P., Casorati, G.. - In: JOURNAL OF IMMUNOLOGY. - ISSN 0022-1767. - 186:7(2011), pp. 4490-4499. [10.4049/jimmunol.1003748]
Invariant NKT cell reconstitution in pediatric leukemia patients given HLA-haploidentical stem cell transplantation defines distinct CD4+ and CD4-subset dynamics and correlates with remission state
Bernardo M. E.Data Curation
;
2011-01-01
Abstract
Immune reconstitution plays a crucial role on the outcome of patients given T cell-depleted HLA-haploidentical hematopoietic stem cell transplantation (hHSCT) for hematological malignancies. CD1d-restricted invariant NKT (iNKT) cells are innate-like, lipidreactive T lymphocytes controlling infections, cancer, and autoimmunity. Adult mature iNKT cells are divided in two functionally distinct CD4+ and CD4- subsets that express the NK receptor CD161 and derive from thymic CD4+CD1612 precursors. We investigated iNKT cell reconstitution dynamics in 33 pediatric patients given hHSCT for hematological malignancies, with a follow-up reaching 6 y posttransplantation, and correlated their emergence with disease relapse. iNKT cells fully reconstitute and rapidly convert into IFN-γ-expressing effectors in the 25 patients maintaining remission. CD4+ cells emerge earlier than the CD4- ones, both displaying CD1612 immature phenotypes. CD4- cells expand more slowly than CD4+ cells, though they mature with significantly faster kinetics, reaching full maturation by 18 mo post-hHSCT. Between 4 and 6 y post-hHSCT, mature CD4- iNKT cells undergo a substantial expansion burst, resulting in a CD4 +I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
