SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers—individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease—present a unique opportunity to reveal human genetic determinants of infection and disease.

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection / Casanova, J. -L.; Su, H. C.; Abel, L.; Aiuti, A.; Almuhsen, S.; Arias, A. A.; Bastard, P.; Biggs, C.; Bogunovic, D.; Boisson, B.; Boisson-Dupuis, S.; Bolze, A.; Bondarenko, A.; Bousfiha, A.; Brodin, P.; Bustamante, J.; Butte, M.; Casari, G.; Ciancanelli, M.; Cobat, A.; Condino-Neto, A.; Cooper, M.; Dalgard, C.; Espinosa, S.; Feldman, H.; Fellay, J.; Franco, J. L.; Hagin, D.; Itan, Y.; Jouanguy, E.; Lucas, C.; Mansouri, D.; Meyts, I.; Milner, J.; Mogensen, T.; Morio, T.; Ng, L.; Notarangelo, L. D.; Okada, S.; Ozcelik, T.; Palacin, P. S.; Planas, A.; Prando, C.; Puel, A.; Pujol, A.; Redin, C.; Renia, L.; Rodriguez Gallego, J. C.; Quintana-Murci, L.; Sancho-Shimizu, V.; Sankaran, V.; Seppanen, M. R. J.; Shahrooei, M.; Snow, A.; Spaan, A.; Tangye, S.; Tur, J. P.; Turvey, S.; Vinh, D. C.; von Bernuth, H.; Wang, X.; Zawadzki, P.; Zhang, Q.; Zhang, S.. - In: CELL. - ISSN 0092-8674. - 181:6(2020), pp. 1194-1199. [10.1016/j.cell.2020.05.016]

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Aiuti A.;Casari G.;
2020-01-01

Abstract

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers—individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease—present a unique opportunity to reveal human genetic determinants of infection and disease.
2020
Age Factors
Betacoronavirus
COVID-19
Coronavirus Infections
Disease Resistance
Genetic Association Studies
Genetic Diseases, Inborn
Genetic Variation
Genome, Human
Host-Pathogen Interactions
Humans
Infections
Pandemics
Pneumonia, Viral
SARS-CoV-2
Genetic Predisposition to Disease
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/107434
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