The recent coronavirus disease 2019 (COVID-19) pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age-dependent disease susceptibility and mortality in the elderly suggest that sex hormones are the main factors in determining the clinical course of the infection. The differences in aging males versus females and the role of sex hormones in key phenotypes of COVID-19 infection are described in this review. Recommendations based on a dimorphic approach for males and females suggest a sex-specific management the disease.
Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality / Brandi, M. L.; Giustina, A.. - In: TRENDS IN ENDOCRINOLOGY AND METABOLISM. - ISSN 1043-2760. - 31:12(2020), pp. 918-927. [10.1016/j.tem.2020.09.003]
Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality
Giustina A.
2020-01-01
Abstract
The recent coronavirus disease 2019 (COVID-19) pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age-dependent disease susceptibility and mortality in the elderly suggest that sex hormones are the main factors in determining the clinical course of the infection. The differences in aging males versus females and the role of sex hormones in key phenotypes of COVID-19 infection are described in this review. Recommendations based on a dimorphic approach for males and females suggest a sex-specific management the disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
