We present, to our knowledge, the first case of immunosuppressive treatment (IST) application in a 12-year old child with arrhythmogenic inflammatory cardiomyopathy (AIC) resulting from the overlap between autoimmune myocarditis and primary arrhythmogenic cardiomyopathy (AC). Indication to off-lable IST was compelling, because of recurrent durg-refractory ventricular arrhythmias. We show that IST was feasible, safe, and effective on multiple clinical endpoints, including symptoms, ventricular arrhythmia recurrences, and T-troponin release. Remarkably, all diagnostic and therapeutic strategies were worked out by a dedicated multidisciplinary team, including specialized pediatric immunologists.
Immunosuppressive therapy in childhood‐onset arrhythmogenic inflammatory cardiomyopathy / Peretto, G., Barzaghi, F., Cicalese, M.P., Resta, C.D., Slavich, M., Benedetti, S., Giangiobbe, S., Rizzo, S., Palmisano, A., Esposito, A., De Cobelli, F., Gulletta, S., Basso, C., Casari, G., Aiuti, A., Bella, P.D., Sala, S.. - In: PACING AND CLINICAL ELECTROPHYSIOLOGY. - ISSN 0147-8389. - 44:3(2021), pp. 552-556. [Epub ahead of print] [10.1111/pace.14153]
Immunosuppressive therapy in childhood‐onset arrhythmogenic inflammatory cardiomyopathy
Cicalese, Maria Pia;Resta, Chiara Di;Palmisano, Anna;Esposito, Antonio;De Cobelli, Francesco;Casari, Giorgio;Aiuti, Alessandro;
2021-01-01
Abstract
We present, to our knowledge, the first case of immunosuppressive treatment (IST) application in a 12-year old child with arrhythmogenic inflammatory cardiomyopathy (AIC) resulting from the overlap between autoimmune myocarditis and primary arrhythmogenic cardiomyopathy (AC). Indication to off-lable IST was compelling, because of recurrent durg-refractory ventricular arrhythmias. We show that IST was feasible, safe, and effective on multiple clinical endpoints, including symptoms, ventricular arrhythmia recurrences, and T-troponin release. Remarkably, all diagnostic and therapeutic strategies were worked out by a dedicated multidisciplinary team, including specialized pediatric immunologists.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
