The addition of fermented milk with plant sterols improves the adherence to lifestyle changes in hypercholesterolemic patients. The RECIPE study

Masana, L.; Lagares, M.; Pinto, X.; Reinares, L.; Zuniga, M.; Descamps, O.; Bosi, E.; Allaert, F. A.; Chapman, J.; Bruckert, E.; Hernandez, T.; Martin, C.; Gomes, H.; Perez, P. J.; Gil, E. M.; Moro, A.; Jorda, M. D.; Lopez, J. L.; Alba, M.; Bilbao, I.; Alustiza, M. R.; Aliaga, M.; Munoz, J. G.; Terol, A. M.; Gomez, P.; Marcos, M. A.; Gonzalez, M.; Rodriguez, M. J.; Lopez, M. V.; Romero, M. A.; Puyo, N.; Egido, J. F.; Monreal, I.; Ramirez, A.; Madariaga, M. A.; De Miguel, M. C.; Lorda, A.; Munoz, G.; Moreno, I. M.; Martinez, A.; Sanchez, A.; Espino, A.; Gonzale, z. F. J.; Pracht, C.; Ocana, C.; Pena, M. A.; Domingo, C.; Gilaberte, M. T.; Garcia, C.; Diez, J. A.; Fornes, F. V.; Gutierrez, M. D.; Macarra, E.; Bugella, J. I.; l. J. M., De; Bravo, A.; Becerra, M. J.; Carbonell, C.; De Miguel, M.; Perez, A.; Martin, A.; Perez, A.; Romero, J.; Gonzalez, P.; Iglesias, A.; Lopez, B.; Villalonga, G.; Carvajal, P.; Marin, C.; Cardona, F.; Gonzalez, A.; Fernandez, G.; Gomez, D.; Sanchez, C. L.; Viveros, D.; De Lucas, M. G.; Marin, J. M.; Osorno, J.; Pumares, C.; Gimenez, R.; Latorre, J.; Barreiro, M. C.; Villanueva, J. R.; Lopez, J. A.; Balaguer, I.; Baron, J.; Espuga, M.; Firas, R.; Trias, F.; Moran, A.; Velasco, V.; Vazquez, F.; Hernando, A.; Manzanares, A.; Abad, J. L.; Peraferrer, M.; Obarrio, A.; Alonso, M. L.; Gomez, L.; Roca, J.; Ayus, B. E.; Urban, F.; Gonzalez, E.; Masegosa, C.; Barrilero, E.; Jimenez, M. C.; Carratala, M. M.; Petitbo, D.; Ferrandiz, J.; Mialdea, M. J.; Montoro, J.; Muncharaz, M. E.; Rodriguez, M. J.; Shehchar, A.; De Paula, L.; Cano, A.; Sanchez, L.; Perez, J.; Alarcon, C.; Martinez, J. F.; Garrido, T.; Martinez, F.; Gomariz, I.; Caparros, M.; Perez, A.; Kseibi, T.; Palomo, L.; Jimenez, T.; Luque, I.; Villar, P.; Gonzalez, J. J.; Aparicio, J.; Jimenez, O.; Munoz, J. J.; Baez, F.; Sanchez, A.; Marcos, M. P.; Gonzalez, T.; Estevez, J. A.; Perez, A.; Garcia, J.; Ajuria-Gogeasko, S.; Cabrera, M.; Manzano, J. M.; Segura, G.; Abat, X.; Yanovsky, N.; Borrachero, J. M.; Fortuny, M.; Martinez, M. D.; Gutierrez, A. R.; Najem, N.; Romero, M. C.; Martin, S.; Valverde, R. J.; Molina, C.; Martinez, B.; Izquierdo, L.; Vazquez, I.; Martinez, M. T.; Mateos, A.; Quiles, F.; Aranda, F. J.; Iborra, R.; Valero, A. B.; Fornes, M. T.; Quinza, V.; Colado, F.; Arribas, B.; Martinez, J. E. L.; Garces, M. P.; Valero, J. M.; Frigola, J. L.; Rubio, J. M.; Gongora, A.; Triana, J.; Gomez, C.; Garcia, M. L.; Diez, C.; Pombo, G.; Gutierrez, M. C.; Nazara, C. A.; De Oca, M. A.; Maquieira, N.; Pilo, A.; Buenadicha, J. L.; Duran, F.; Pena, J. E.; Navarro, S.; Serrano, F. J.; Sanchez, S.; Mesa, S.; Salazar, J. A.; De La Escosura, A.; Perez, F.; Solera, J.; Tarraga, P.; Ramos, L.; Gutierrez, J. A.; Caldelas, S.; Albinana, F.; Lopez, J. F.; Florian, J.; Rocha, E.; Rodriguez, J.; Mellado, M. L.; Calvillo, M. R.; Cruz, T.; Capitan, M.; Diaz, J.; Tome, J.; Prieto, A.; Tome, V.; Caro, M.; Montero, A.; Ontoria, M.; Garcia, D. L.; Gil, F.; De Zarate, V.; Gonzalez, A.; Baron, J.; Casaponsa, J.; Matamala, J.; Salvande, A.; Trueba, M. A.; Cidra, J. L.; Garcia, A.; Toro, A.; Berna, J. R.; Zornoza, B.; Prieto, M. T.; Garcia, L.; Lopez, C.; Garcia, P.; Echegaray, M. C.; Navarro, B.; Moro, M. L.; Herrero, A.; Tamargo, C.; Perez, S. J.; Antero, E.; Penacho, M. C.; Blanco, Y.; Lucena, J.; Sisto, C. A.; Salido, E.; Dolz, F.; Granja, J. M.; Saavedra, F.; Sanchez-Oro, I.; Mas-Magro, F.; Artundo, T.; Fernandez, A.; Vaquer, J. V.; Aso, K.; Palacios, A.; Morante, J. L.; Seller, T.; Vendrell, J. M.

doi:10.1016/j.arteri.2012.04.004

Introduction: RECIPE study was designed to assess the impact of dietary supplementation with fermented milk enriched with plant sterols (FMPS) on the nutritional behavior, lifestyle and the joint therapeutic responsibility of hypercholesterolemic patients. Methods: Observational, prospective, multicenter, international study, was conducted to assess dietary habits and other lifestyle components in hypercholesterolemic patients in whom the general practitioner indicated FMPS supplementation. Nutritional, lifestyle and clinical data were collected at the initial visit and after a 4 months follow-up. The biochemical and anthropometric data were retrieved from medical records obtained at baseline and 4 months. Results: We report the results of Spain. Two hundred and one physicians who provided valid data of 1044 patients participated. The addition of FMPS was associated with improved overall nutritional index, being adequate initially in 28.2% of patients, and increasing up to 75.2% at the end of the study (P< 001). This nutritional change was associated with an improvement in the lipid profile and anthropometric data. Patients more adherent to therapy generally achieved a better result in all parameters compared to non-compliant ones. Conclusions: The addition of FMPS to a diet designed to reduce the LDL enhances the patient's attitude regarding changes in lifestyle, leading to better overall control of dyslipidemia and anthropometric improvement. © 2012 Elsevier España, S.L. and SEA.