Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is primarily diagnosed through viral RNA positivity in nasopharyngeal swabs, and it is associated with the early detection of specific immunoglobulins to SARS-CoV-2 proteins. We describe two moderate coronavirus disease 2019 (COVID-19) patients with WHO score 4/5 at the time of hospitalization, pneumonia, and oxygen saturation <94% and with a strong discrepancy between viral RNA and antibodies to SARS-CoV-2. One patient was positive for viral RNA but completely negative for binding and neutralizing antibodies, whereas the second patient was negative for viral RNA but with high levels of both neutralizing and binding antibodies. This observation is relevant to better understand the pathogenesis of this novel infection.

Virological and Serological Discordant Profiles in COVID-19 Pneumonia: Two Atypical Clinical Cases / Ranzenigo, M.; Pastori, C.; Siracusano, G.; Pariani, E.; Uberti-Foppa, C.; Lopalco, L.. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 11:(2020), p. 580867. [Epub ahead of print] [10.3389/fimmu.2020.580867]

Virological and Serological Discordant Profiles in COVID-19 Pneumonia: Two Atypical Clinical Cases

Ranzenigo M.;Uberti-Foppa C.;
2020-01-01

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is primarily diagnosed through viral RNA positivity in nasopharyngeal swabs, and it is associated with the early detection of specific immunoglobulins to SARS-CoV-2 proteins. We describe two moderate coronavirus disease 2019 (COVID-19) patients with WHO score 4/5 at the time of hospitalization, pneumonia, and oxygen saturation <94% and with a strong discrepancy between viral RNA and antibodies to SARS-CoV-2. One patient was positive for viral RNA but completely negative for binding and neutralizing antibodies, whereas the second patient was negative for viral RNA but with high levels of both neutralizing and binding antibodies. This observation is relevant to better understand the pathogenesis of this novel infection.
2020
antibodies
COVID-19
neutralizing antibodies
NP
PCR
SARS-CoV-2
spike protein
viral RNA
Aged
Antibodies, Neutralizing
Antibodies, Viral
COVID-19
COVID-19 Testing
Clinical Laboratory Techniques
Coronavirus Infections
Female
Humans
Male
Nasal Mucosa
Pandemics
Pneumonia, Viral
RNA, Viral
Real-Time Polymerase Chain Reaction
Serologic Tests
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/109705
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