Care-related infections affect up to 11% of ICU patients. Running therapeutic albumin is sometimes associated to less infection: whether a specific method of its infusion is of any interest to modulate innate defense is unknown. Our objectives were: 1) to test whether the method for albumin infusion is important to prevent care-related infections and 2) to analyze in vitro the antioxidative role of albumin on host defense proteins during shock (using vasostatin-I as an example).
A Pilot Study on Continuous Infusion of 4% Albumin in Critically Ill Patients: Impact on Nosocomial Infection via a Reduction Mechanism for Oxidized Substrates / Schneider, Francis; Dureau, Anne-Florence; Hellé, Sophie; Betscha, Cosette; Senger, Bernard; Cremel, Gérard; Boulmedais, Fouzia; Strub, Jean-Marc; Corti, Angelo; Meyer, Nicolas; Guillot, Max; Schaaf, Pierre; Metz-Boutigue, Marie-Hélène. - In: CRITICAL CARE EXPLORATIONS. - ISSN 2639-8028. - 1:9(2019), p. e0044. [10.1097/CCE.0000000000000044]
A Pilot Study on Continuous Infusion of 4% Albumin in Critically Ill Patients: Impact on Nosocomial Infection via a Reduction Mechanism for Oxidized Substrates
Corti, Angelo;
2019-01-01
Abstract
Care-related infections affect up to 11% of ICU patients. Running therapeutic albumin is sometimes associated to less infection: whether a specific method of its infusion is of any interest to modulate innate defense is unknown. Our objectives were: 1) to test whether the method for albumin infusion is important to prevent care-related infections and 2) to analyze in vitro the antioxidative role of albumin on host defense proteins during shock (using vasostatin-I as an example).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
