A retrospective analysis of genomic alterations in pure bladder adenocarcinoma and pure squamous-cell carcinoma, compared with the classical urothelial carcinoma, revealed similar opportunities for immunotherapy between urothelial carcinoma and squamous-cell tumors, whereas adenocarcinoma cases expressed immunotherapy biomarkers less frequently. The landscape of genomic alterations between these rare histologies was different.

Comprehensive Assessment of Immuno-oncology Biomarkers in Adenocarcinoma, Urothelial Carcinoma, and Squamous-cell Carcinoma of the Bladder

Necchi A.;
2020-01-01

Abstract

A retrospective analysis of genomic alterations in pure bladder adenocarcinoma and pure squamous-cell carcinoma, compared with the classical urothelial carcinoma, revealed similar opportunities for immunotherapy between urothelial carcinoma and squamous-cell tumors, whereas adenocarcinoma cases expressed immunotherapy biomarkers less frequently. The landscape of genomic alterations between these rare histologies was different.
2020
Inglese
Elsevier B.V.
77
4
548
556
9
Pubblicato
Bladder adenocarcinoma
Bladder squamous-cell carcinoma
Genomic alterations
Immunotherapy biomarkers
Variant histologies
none
23
info:eu-repo/semantics/article
262
Necchi, A.; Madison, R.; Raggi, D.; Jacob, J. M.; Bratslavsky, G.; Shapiro, O.; Elvin, J. A.; Vergilio, J. -A.; Killian, J. K.; Ngo, N.; Ramkissoon, S...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/110079
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