Recently, microRNAs (miRNAs) were identified able to inhibit the expression of the Cystic Fibrosis Transmembrane Regulator (CFTR) disease-gene of Cystic Fibrosis (CF) and CFTR-Related Disorders (CFTR-RD). This study shows the use of peptide nucleic acids (PNAs) as inhibitors of miR-509-3p, one of the CFTR regulating miRNAs, by reverting the expression of luciferase gene containing the 3 'UTR of CFTR gene.

Design, synthesis and biochemical investigation, by in vitro luciferase reporter system, of peptide nucleic acids as new inhibitors of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression / Amato, Felice; Tomaiuolo, Rossella; Borbone, Nicola; Ausilia, Elce; Amato, Jussara; D'Errico, Stefano; DE ROSA, Giuseppe; Mayol, Laura; Piccialli, Gennaro; Oliviero, Giorgia; Castaldo, Giuseppe. - In: MEDCHEMCOMM. - ISSN 2040-2503. - 5:1(2014), pp. 68-71. [10.1039/C3MD00257H]

Design, synthesis and biochemical investigation, by in vitro luciferase reporter system, of peptide nucleic acids as new inhibitors of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression

TOMAIUOLO, ROSSELLA;
2014-01-01

Abstract

Recently, microRNAs (miRNAs) were identified able to inhibit the expression of the Cystic Fibrosis Transmembrane Regulator (CFTR) disease-gene of Cystic Fibrosis (CF) and CFTR-Related Disorders (CFTR-RD). This study shows the use of peptide nucleic acids (PNAs) as inhibitors of miR-509-3p, one of the CFTR regulating miRNAs, by reverting the expression of luciferase gene containing the 3 'UTR of CFTR gene.
2014
Inglese
5
1
68
71
4
http://pubs.rsc.org/en/content/articlelanding/2014/md/c3md00257h#!divAbstract
Esperti anonimi
TRANSMEMBRANE CONDUCTANCE REGULATOR
PNA
DNA
OLIGONUCLEOTIDES
HYBRIDIZATION
MICRORNAS
GENE
Design, synthesis and biochemical investigation, by in vitro luciferase reporter system, of peptide nucleic acids as new inhibitors of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression / Amato, Felice; Tomaiuolo, Rossella; Borbone, Nicola; Ausilia, Elce; Amato, Jussara; D'Errico, Stefano; DE ROSA, Giuseppe; Mayol, Laura; Piccialli, Gennaro; Oliviero, Giorgia; Castaldo, Giuseppe. - In: MEDCHEMCOMM. - ISSN 2040-2503. - 5:1(2014), pp. 68-71. [10.1039/C3MD00257H]
none
11
info:eu-repo/semantics/article
262
Amato, Felice; Tomaiuolo, Rossella; Borbone, Nicola; Ausilia, Elce; Amato, Jussara; D'Errico, Stefano; DE ROSA, Giuseppe; Mayol, Laura; Piccialli, Gen...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/111517
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