BACKGROUND: Data are limited regarding bone metastases from colorectal cancer (CRC). The objective of this study was to survey the natural history of bone metastasis in CRC.PATIENTS AND METHODS: This retrospective, multicenter, observational study of 264 patients with CRC involving bone examined cancer treatments, bone metastases characteristics, skeletal-related event (SRE) type and frequency, zoledronic acid therapy, and disease outcomes.RESULTS: Most patients with bone metastases had pathologic T3/4 disease at CRC diagnosis. The spine was the most common site involved (65%), followed by hip/pelvis (34%), long bones (26%), and other sites (17%). Median time from CRC diagnosis to bone metastases was 11.00 months; median time to first SRE thereafter was 2.00 months. Radiation and pathologic fractures affected 45% and 10% of patients, respectively; 32% of patients had no reported SREs. Patients survived for a median of 7.00 months after bone metastases diagnosis; SREs did not significantly affect survival. Subgroup analyses revealed that zoledronic acid significantly prolonged median time to first SRE (2.00 months versus 1.00 month, respectively, P=0.009) and produced a trend toward improved overall survival versus no zoledronic acid.CONCLUSION: This study illustrates the burden of bone metastases from CRC and supports the use of zoledronic acid in this setting
Natural history of bone metastasis in colorectal cancer: final results of a large Italian bone metastases study / Santini, D; Tampellini, M; Vincenzi, B; Ibrahim, T; Ortega, C; Virzi, V; Silvestris, N; Berardi, R; Masini, C; Calipari, N; Ottaviani, D; Catalano, V; Badalamenti, G; Giannicola, R; Fabbri, F; Venditti, O; Fratto, Me; Mazzara, C; Latiano, Tp; Bertolini, F; Petrelli, F; Ottone, A; Caroti, C; Salvatore, L; Falcone, A; Giordani, P; Addeo, R; Aglietta, M; Cascinu, Stefano; Barni, S; Maiello, E; Tonini, G.. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 23:(2012), pp. 2072-2077. [10.1093/annonc/mdr572]
Natural history of bone metastasis in colorectal cancer: final results of a large Italian bone metastases study
CASCINU, Stefano;
2012-01-01
Abstract
BACKGROUND: Data are limited regarding bone metastases from colorectal cancer (CRC). The objective of this study was to survey the natural history of bone metastasis in CRC.PATIENTS AND METHODS: This retrospective, multicenter, observational study of 264 patients with CRC involving bone examined cancer treatments, bone metastases characteristics, skeletal-related event (SRE) type and frequency, zoledronic acid therapy, and disease outcomes.RESULTS: Most patients with bone metastases had pathologic T3/4 disease at CRC diagnosis. The spine was the most common site involved (65%), followed by hip/pelvis (34%), long bones (26%), and other sites (17%). Median time from CRC diagnosis to bone metastases was 11.00 months; median time to first SRE thereafter was 2.00 months. Radiation and pathologic fractures affected 45% and 10% of patients, respectively; 32% of patients had no reported SREs. Patients survived for a median of 7.00 months after bone metastases diagnosis; SREs did not significantly affect survival. Subgroup analyses revealed that zoledronic acid significantly prolonged median time to first SRE (2.00 months versus 1.00 month, respectively, P=0.009) and produced a trend toward improved overall survival versus no zoledronic acid.CONCLUSION: This study illustrates the burden of bone metastases from CRC and supports the use of zoledronic acid in this settingI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
