The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7 mJ/cm2 was sufficient to achieve a more than 3-log inactivation without any sign of viral replication. Moreover, a complete inactivation at all viral concentrations was observed with 16.9 mJ/cm2. These results could explain the epidemiological trends of COVID-19 and are important for the development of novel sterilizing methods to contain SARS-CoV-2 infection.
UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication / Biasin, Mara; Bianco, Andrea; Pareschi, Giovanni; Cavalleri, Adalberto; Cavatorta, Claudia; Fenizia, Claudio; Galli, Paola; Lessio, Luigi; Lualdi, Manuela; Tombetti, Enrico; Ambrosi, Alessandro; Redaelli, Edoardo Maria Alberto; Saulle, Irma; Trabattoni, Daria; Zanutta, Alessio; Clerici, Mario. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 11:1(2021), p. 6260. [10.1038/s41598-021-85425-w]
UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication
Ambrosi, Alessandro;
2021-01-01
Abstract
The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7 mJ/cm2 was sufficient to achieve a more than 3-log inactivation without any sign of viral replication. Moreover, a complete inactivation at all viral concentrations was observed with 16.9 mJ/cm2. These results could explain the epidemiological trends of COVID-19 and are important for the development of novel sterilizing methods to contain SARS-CoV-2 infection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
