SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral re-sponse. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with ad-vantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.
Characterization of a lineage c.36 sars-cov-2 isolate with reduced susceptibility to neutralization circulating in lombardy, italy / Castelli, Matteo; Baj, Andreina; Criscuolo, Elena; Ferrarese, Roberto; Diotti, Roberta A.; Sampaolo, Michela; Novazzi, Federica; Dalla Gasperina, Daniela; Focosi, Daniele; Ferrari, Davide; Locatelli, Massimo; Clementi, Massimo; Clementi, Nicola; Maggi, Fabrizio; Mancini, Nicasio. - In: VIRUSES. - ISSN 1999-4915. - 13:8(2021), p. 1514. [10.3390/v13081514]
Characterization of a lineage c.36 sars-cov-2 isolate with reduced susceptibility to neutralization circulating in lombardy, italy
Castelli, MatteoCo-primo
;Criscuolo, ElenaSecondo
;Clementi, Massimo;Clementi, Nicola;Mancini, Nicasio
Ultimo
2021-01-01
Abstract
SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral re-sponse. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with ad-vantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
