Sphingosine-1-phosphate receptor 2 (S1PR2) mediates pleiotropic functions encompassing cell proliferation, survival, and migration, which become collectively de-regulated in cancer. Information on whether S1PR2 participates in colorectal carcinogenesis/cancer is scanty, and we set out to fill the gap.

Unveiling role of sphingosine-1-phosphate receptor 2 as a brake of epithelial stem cell proliferation and a tumor suppressor in colorectal cancer / Petti, Luciana; Rizzo, Giulia; Rubbino, Federica; Elangovan, Sudharshan; Colombo, Piergiuseppe; Restelli, Silvia; Piontini, Andrea; Arena, Vincenzo; Carvello, Michele; Romano, Barbara; Cavalleri, Tommaso; Anselmo, Achille; Ungaro, Federica; D'Alessio, Silvia; Spinelli, Antonino; Stifter, Sanja; Grizzi, Fabio; Sgambato, Alessandro; Danese, Silvio; Laghi, Luigi; Malesci, Alberto; Vetrano, Stefania. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 39:1(2020), p. 253. [10.1186/s13046-020-01740-6]

Unveiling role of sphingosine-1-phosphate receptor 2 as a brake of epithelial stem cell proliferation and a tumor suppressor in colorectal cancer

Danese, Silvio;
2020-01-01

Abstract

Sphingosine-1-phosphate receptor 2 (S1PR2) mediates pleiotropic functions encompassing cell proliferation, survival, and migration, which become collectively de-regulated in cancer. Information on whether S1PR2 participates in colorectal carcinogenesis/cancer is scanty, and we set out to fill the gap.
2020
Colorectal cancer
Epithelial proliferation
PTEN
S1PR2
Lgr5
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/119473
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