Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate immunity that is essential for resistance to certain pathogens. A regulatory role for pentraxins in inflammation has long been recognized, but the underlying mechanisms remain unclear. Here we report that PTX3 bound P-selectin and attenuated neutrophil recruitment at sites of inflammation. PTX3 released from activated leukocytes functioned locally to dampen neutrophil recruitment and regulate inflammation. Antibodies have glycosylation-dependent regulatory effect on inflammation. Therefore, PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown here, glycosylation-dependent regulation of inflammation. RI Russo, Remo/F-9048-2010
Regulation of leukocyte recruitment by the long pentraxin PTX3 / Deban, L; Russo, Rc; Sironi, M; Moalli, F; Scanziani, M; Zambelli, V; Cuccovillo, I; Bastone, A; Gobbi, M; Valentino, S; Doni, A; Garlanda, C; Danese, S; Salvatori, G; Sassano, M; Evangelista, V; Rossi, B; Zenaro, E; Constantin, G; Laudanna, C; Bottazzi, B; Mantovani, A.. - In: NATURE IMMUNOLOGY. - ISSN 1529-2908. - 11:4(2010), pp. 328-U74. [10.1038/ni.1854]
Regulation of leukocyte recruitment by the long pentraxin PTX3
Danese S;
2010-01-01
Abstract
Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate immunity that is essential for resistance to certain pathogens. A regulatory role for pentraxins in inflammation has long been recognized, but the underlying mechanisms remain unclear. Here we report that PTX3 bound P-selectin and attenuated neutrophil recruitment at sites of inflammation. PTX3 released from activated leukocytes functioned locally to dampen neutrophil recruitment and regulate inflammation. Antibodies have glycosylation-dependent regulatory effect on inflammation. Therefore, PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown here, glycosylation-dependent regulation of inflammation. RI Russo, Remo/F-9048-2010I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
