The aim of this study was to review the quality of the diagnostic work-up for acute encephalitis carried out at our center in a cohort of patients with hematological disorders. Our data showed substantial heterogeneity in investigating patients. Not all patients had their CSF tested for viruses commonly responsible for encephalitis in immunocompetent individuals (e.g., VZV, enterovirus). A blood sample for the calculation of the CSF/blood replication ratio was collected in 74% of cases. CSF cultures and immunophenotyping of CSF cells were performed in 77% and 21% of patients, respectively. A multidisciplinary consensus is needed to improve current guidelines and standardize diagnostic protocols.
Diagnosing acute encephalitis in patients with hematological disorders: caveats and pitfalls / Vegezzi, E.; Berzero, G.; Barbetta, D.; Colombo, A. A.; Borsani, O.; Bernasconi, P.; Compagno, F.; Zecca, M.; Campanini, G.; Simoncelli, A.; Paoletti, M.; Pichiecchio, A.; Baldanti, F.; Brunetti, E.; Marchioni, E.. - In: JOURNAL OF NEUROVIROLOGY. - ISSN 1355-0284. - 26:2(2020), pp. 257-263. [10.1007/s13365-019-00817-z]
Diagnosing acute encephalitis in patients with hematological disorders: caveats and pitfalls
Berzero G.;
2020-01-01
Abstract
The aim of this study was to review the quality of the diagnostic work-up for acute encephalitis carried out at our center in a cohort of patients with hematological disorders. Our data showed substantial heterogeneity in investigating patients. Not all patients had their CSF tested for viruses commonly responsible for encephalitis in immunocompetent individuals (e.g., VZV, enterovirus). A blood sample for the calculation of the CSF/blood replication ratio was collected in 74% of cases. CSF cultures and immunophenotyping of CSF cells were performed in 77% and 21% of patients, respectively. A multidisciplinary consensus is needed to improve current guidelines and standardize diagnostic protocols.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
