Uromodulin (or Tamm-Horsfall protein) is the most abundant protein in human urine under physiological conditions. Little is known about the molecular mechanism of uromodulin secretion. By extensive Mass Spectrometry analyses we mapped the C-termini of human and murine urinary proteins demonstrating that urinary uromodulin is generated by a conserved C-terminal proteolytic cleavage and retains its entire ZP domain. (c) 2008 Elsevier Inc. All rights reserved.
Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage / Santambrogio, S; Cattaneo, A; Bernascone, I; Schwend, T; Jovine, L; Bachi, A; Rampoldi, L. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - 370:3(2008), pp. 410-413. [10.1016/j.bbrc.2008.03.099]
Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage
Rampoldi L
2008-01-01
Abstract
Uromodulin (or Tamm-Horsfall protein) is the most abundant protein in human urine under physiological conditions. Little is known about the molecular mechanism of uromodulin secretion. By extensive Mass Spectrometry analyses we mapped the C-termini of human and murine urinary proteins demonstrating that urinary uromodulin is generated by a conserved C-terminal proteolytic cleavage and retains its entire ZP domain. (c) 2008 Elsevier Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
