In this randomized, single-centre, open-label, 96-week, superiority, controlled trial of 50 HIV-infected patients with HIV-RNA less than 50 copies/ml on a two-drug regimen based on dolutegravir as well as one reverse transcriptase inhibitor (RTI), switching to a single-tablet regimen of cobicistat, elvitregravir, emtricitabine along with tenofovir alafenamide did not appear to mitigate the burden of residual viremia, both at week 48 and at week 96. The immunological changes observed during follow-up and the safety of the two regimens were similar.
Residual viremia in HIV-infected patients who continue a two-drug or switch to a three-drug integrase strand transfer inhibitor based regimen / Gianotti, N.; Galli, L.; Poli, A.; Torre, L. D.; Vinci, C.; Carini, E.; Galli, A.; Nozza, S.; Spagnuolo, V.; Muccini, C.; Lazzarin, A.; Castagna, A.. - In: AIDS. - ISSN 1473-5571. - 35:9(2021), pp. 1513-1516. [10.1097/QAD.0000000000002908]
Residual viremia in HIV-infected patients who continue a two-drug or switch to a three-drug integrase strand transfer inhibitor based regimen
Nozza S.;Muccini C.Membro del Collaboration Group
;Lazzarin A.Membro del Collaboration Group
;Castagna A.Membro del Collaboration Group
2021-01-01
Abstract
In this randomized, single-centre, open-label, 96-week, superiority, controlled trial of 50 HIV-infected patients with HIV-RNA less than 50 copies/ml on a two-drug regimen based on dolutegravir as well as one reverse transcriptase inhibitor (RTI), switching to a single-tablet regimen of cobicistat, elvitregravir, emtricitabine along with tenofovir alafenamide did not appear to mitigate the burden of residual viremia, both at week 48 and at week 96. The immunological changes observed during follow-up and the safety of the two regimens were similar.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
