Background: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim: To assess how many years of life are lost after HCC diagnosis. Methods: Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results: Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18-61 years) had the highest number of years-of-life lost, representing approximately 41% of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986-1999, to 10.7 in 2000-2006 and 7.4 years in 2007-2014. Currently, an HCC diagnosis when a single tumour <2 cm results in 3.7 years-of-life lost while the diagnosis when a single tumour ≥2 cm or 2/3 nodules still within the Milan criteria, results in 5.0 years-of-life lost, representing the loss of only approximately 5.5% and 7.2%, respectively, of the entire lifespan from birth. Conclusions: Hepatocellular carcinoma occurrence results in the loss of a considerable number of years-of-life, especially for younger patients. In recent years, the increased possibility of effectively treating this tumour has improved life expectancy, thus reducing years-of-life lost.
Years of life that could be saved from prevention of hepatocellular carcinoma / Cucchetti, A.; Trevisani, F.; Bucci, L.; Ravaioli, M.; Farinati, F.; Giannini, E. G.; Ciccarese, F.; Piscaglia, F.; Rapaccini, G. L.; Di Marco, M.; Caturelli, E.; Zoli, M.; Borzio, F.; Sacco, R.; Maida, M.; Felder, M.; Morisco, F.; Gasbarrini, A.; Gemini, S.; Foschi, F. G.; Missale, G.; Masotto, A.; Affronti, A.; Bernardi, M.; Pinna, A. D.; Bolondi, L.; Biselli, M.; Caraceni, P.; Domenicali, M.; Gramenzi, A.; Magalotti, D.; Pecorelli, A.; Serra, C.; Venerandi, L.; Gazzola, A.; Murer, F.; Pozzan, C.; Vanin, V.; Del Poggio, P.; Olmi, S.; Balsamo, C.; Vavassori, E.; Benvegnu, L.; Cappelli, A.; Golfieri, R.; Mosconi, C.; Renzulli, M.; Bosco, G.; Roselli, P.; Dell'Isola, S.; Lalungo, A. M.; Rastrelli, E.; Moscatelli, A.; Pellegatta, G.; Picciotto, A.; Savarino, V.; Barcellona, M. R.; Camma, C.; Cabibbo, G.; Costantino, A.; Virdone, R.; Mega, A.; Rinninella, E.; Mismas, V.; Dall'Aglio, A. C.; Feletti, V.; Lanzi, A.; Cappa, F. M.; Neri, E.; Stefanini, G. F.; Tamberi, S.; Biasini, E.; Porro, E.; Guarino, M.; Baroni, G. S.; Schiada, L.; Chiaramonte, M.; Marchetti, F.; Valerio, M.. - In: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. - ISSN 0269-2813. - 43:7(2016), pp. 814-824. [10.1111/apt.13554]
Years of life that could be saved from prevention of hepatocellular carcinoma
Olmi S.;
2016-01-01
Abstract
Background: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim: To assess how many years of life are lost after HCC diagnosis. Methods: Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results: Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18-61 years) had the highest number of years-of-life lost, representing approximately 41% of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986-1999, to 10.7 in 2000-2006 and 7.4 years in 2007-2014. Currently, an HCC diagnosis when a single tumour <2 cm results in 3.7 years-of-life lost while the diagnosis when a single tumour ≥2 cm or 2/3 nodules still within the Milan criteria, results in 5.0 years-of-life lost, representing the loss of only approximately 5.5% and 7.2%, respectively, of the entire lifespan from birth. Conclusions: Hepatocellular carcinoma occurrence results in the loss of a considerable number of years-of-life, especially for younger patients. In recent years, the increased possibility of effectively treating this tumour has improved life expectancy, thus reducing years-of-life lost.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
