Purpose: To compare valacyclovir to acyclovir in preventing recurrences of herpes simplex virus (HSV) eye disease. Methods: Fifty-two patients with recurrent HSV disease were randomized (25 with valacyclovir 500 mg/day; 27 with acyclovir 800 mg/day for one year). Results: Recurrence rate of ocular HSV disease was 24.0% in the valacyclovir group, 22.2% in the acyclovir group (P > .05). No differences were found in the two groups regarding adverse reaction (most frequent were nausea, headache). No serious complications occurred in either group. Conclusion: In this study, the efficacy of onr-year suppression therapy with oral valacyclovir was comparable to acyclovir in reducing the recurrence rate of ocular HSV.
Efficacy of Valacyclovir vs. Acyclovir in Prevention of Recurrent Herpes Simplex Virus Eye Disease
Miserocchi E;
2005-01-01
Abstract
Purpose: To compare valacyclovir to acyclovir in preventing recurrences of herpes simplex virus (HSV) eye disease. Methods: Fifty-two patients with recurrent HSV disease were randomized (25 with valacyclovir 500 mg/day; 27 with acyclovir 800 mg/day for one year). Results: Recurrence rate of ocular HSV disease was 24.0% in the valacyclovir group, 22.2% in the acyclovir group (P > .05). No differences were found in the two groups regarding adverse reaction (most frequent were nausea, headache). No serious complications occurred in either group. Conclusion: In this study, the efficacy of onr-year suppression therapy with oral valacyclovir was comparable to acyclovir in reducing the recurrence rate of ocular HSV.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
