Immune recovery uveitis in a iatrogenically immunosuppressed patient

PURPOSE. To report a case of immune recovery uveitis (IRU) in an iatrogenically immunosuppressed human immunodeficiency virus (HIV)-negative patient. METHODS. Interventional case report. One patient was diagnosed with cytomegalo virus retinitis in the left eye while receiving immunosuppressive treatment following renal transplantation. The retinitis resolved completely with systemic ganciclovir. Further reduction of immunosuppressive treatment, causing a rapid increase in CD4-T lymphocyte count, was associated in the same eye with the occurrence of IRU consisting of anterior uveitis, vitritis, and macular edema. RESULTS. Visual acuity at IRU presentation onset was 201200 in the left eye. After 6 weeks of follow-up, the uveitis resolved with topical and periocular steroid treatment. Visual acuity restored to 20/40. CONCLUSIONS. IRU can occur in iatrogenically immunosuppressed HIV-negative patients.