Postoperative acute kidney injury (AKI) is frequent in cardiac surgery patients. Its pathophysiology is complex and involves decreased renal perfusion. Preliminary clinical evidence in critically ill patients shows that amino acids infusion increases renal blood flow and may decrease the incidence and severity of AKI. We designed a study to evaluate the effectiveness of perioperative continuous infusion of amino acids in decreasing AKI.
Intravenous amino acid therapy for kidney protection in cardiac surgery a protocol for a multi-Centre randomized blinded placebo controlled clinical trial. The PROTECTION trial / Landoni, Giovanni; Brambillasca, Claudio; Redaelli, Martina Baiardo; Bradić, Nikola; Ti, Lian Kah; Povšić-Čevra, Zdenko; Nepomniashchikh, Valery A; Zoccai, Giuseppe Biondi; D'Ascenzo, Fabrizio; Romagnoli, Enrico; Scandroglio, Anna Mara; Ballotta, Andrea; Rondello, Nicola; Franco, Annalisa; Massaro, Cristiano; Viscido, Cristina; Calabrò, Maria Grazia; Garofalo, Eugenio; Canichella, Flaminia; Monaco, Fabrizio; Severi, Luca; Pisano, Antonio; Barucco, Gaia; Venditto, Maria; Federici, Francesco; Licheri, Margherita; Paternoster, Gianluca; Trompeo, Annachiara; Belletti, Alessandro; Mantovani, Lorenzo Filippo; Perone, Romina; Dalessandro, Giuseppe; Kroeller, Daniel; Haxhiademi, Dorela; Galbiati, Carola; Tripodi, Vincenzo Francesco; Giardina, Giuseppe; Lembo, Rosalba; Nakhnoukh, Cristina; Guarracino, Fabio; Longhini, Federico; Bove, Tiziana; Zangrillo, Alberto; Bellomo, Rinaldo; Fominskiy, Evgeny. - In: CONTEMPORARY CLINICAL TRIALS. - ISSN 1551-7144. - 121:(2022). [10.1016/j.cct.2022.106898]
Intravenous amino acid therapy for kidney protection in cardiac surgery a protocol for a multi-Centre randomized blinded placebo controlled clinical trial. The PROTECTION trial
Landoni, Giovanni
Primo
;Belletti, Alessandro;Zangrillo, Alberto;
2022-01-01
Abstract
Postoperative acute kidney injury (AKI) is frequent in cardiac surgery patients. Its pathophysiology is complex and involves decreased renal perfusion. Preliminary clinical evidence in critically ill patients shows that amino acids infusion increases renal blood flow and may decrease the incidence and severity of AKI. We designed a study to evaluate the effectiveness of perioperative continuous infusion of amino acids in decreasing AKI.| File | Dimensione | Formato | |
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