No single reliable biomarker is available for nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs). Vasostatin-1 (VS-1), the N-terminal fragment of chromogranin A (CgA), seems to be a more accurate biomarker compared to its precursor. Primary aim was to investigate the ability of VS-1, compared to total-CgA, to assess the effectiveness of surgical resection performed for NF-PanNETs. Secondary aim was to evaluate two additional CgA-derived fragments, pancreastatin (PST) and vasostatin-2 (VS-2), as possible biomarkers for NF-PanNETs.
Role of chromogranin A-derived fragments after resection of nonfunctioning pancreatic neuroendocrine tumors / Andreasi, V; Partelli, S; Manzoni, M F; Muffatti, F; Di Filippo, L; Crippa, S; Corti, A; Falconi, M. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 1720-8386. - 45:6(2022), pp. 1209-1217. [10.1007/s40618-022-01750-5]