Dysfunctional glutamatergic neurotransmission has been proposed both, as a biological underpinning of mood disorder and as a target for rapid-acting antidepressant treatments. Total sleep deprivation and light therapy (TSD + LT) can prompt antidepressant response in drug-resistant bipolar depression. Here we explored the effects of TSD + LT on dorsolateral prefrontal cortex (DLPFC) glutamate and/or glutamine+glutamate (Glx) levels.

Antidepressant chronotherapeutics normalizes prefrontal 1H-MRS glutamate in bipolar depression

Bravi, Beatrice;Poletti, Sara;Benedetti, Francesco
2022-01-01

Abstract

Dysfunctional glutamatergic neurotransmission has been proposed both, as a biological underpinning of mood disorder and as a target for rapid-acting antidepressant treatments. Total sleep deprivation and light therapy (TSD + LT) can prompt antidepressant response in drug-resistant bipolar depression. Here we explored the effects of TSD + LT on dorsolateral prefrontal cortex (DLPFC) glutamate and/or glutamine+glutamate (Glx) levels.
Bipolar disorder
Chronoterapeutics
Clinical biomarker
Glutamate
Spectroscopy
Antidepressive Agents
Drug Chronotherapy
Glutamic Acid
Glutamine
Humans
Prefrontal Cortex
Proton Magnetic Resonance Spectroscopy
Bipolar Disorder
Depressive Disorder, Major
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/132114
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