Gene mutational profile of BRCAness and clinical implication in predicting response to platinum-based chemotherapy in patients with intrahepatic cholangiocarcinoma

Rimini, Margherita; Macarulla, Teresa; Burgio, Valentina; Lonardi, Sara; Niger, Monica; Scartozzi, Mario; Rapposelli, Ilario G; Aprile, Giuseppe; Ratti, Francesca; Pedica, Federica; Verdaguer, Helena; Nappo, Floriana; Nichetti, Federico; Lai, Eleonora; Valgiusti, Martina; Cappetta, Alessandro; Febregat, Carles; Fassan, Matteo; De Braud, Filippo; Puzzoni, Marco; Frassineti, Giovanni L; Simionato, Francesca; De Cobelli, Francesco; Aldrighetti, Luca; Fornaro, Lorenzo; Cascinu, Stefano; Casadei-Gardini, Andrea

doi:10.1016/j.ejca.2022.05.004

Biliary tract cancers are rare malignancies with a poor prognosis and scarce therapeutic strategies. The significance of BRCAness in this setting is already unknown.

Gene mutational profile of BRCAness and clinical implication in predicting response to platinum-based chemotherapy in patients with intrahepatic cholangiocarcinoma / Rimini, Margherita; Macarulla, Teresa; Burgio, Valentina; Lonardi, Sara; Niger, Monica; Scartozzi, Mario; Rapposelli, Ilario G; Aprile, Giuseppe; Ratti, Francesca; Pedica, Federica; Verdaguer, Helena; Nappo, Floriana; Nichetti, Federico; Lai, Eleonora; Valgiusti, Martina; Cappetta, Alessandro; Febregat, Carles; Fassan, Matteo; De Braud, Filippo; Puzzoni, Marco; Frassineti, Giovanni L; Simionato, Francesca; De Cobelli, Francesco; Aldrighetti, Luca; Fornaro, Lorenzo; Cascinu, Stefano; Casadei-Gardini, Andrea. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 1879-0852. - 171:(2022), pp. 232-241. [10.1016/j.ejca.2022.05.004]