Cholangiocarcinoma (CCA) is still a deadly tumour. Histological and molecular aspects of thioacetamide (TAA)-induced intrahepatic CCA (iCCA) in rats mimic those of human iCCA. Carcinogenic changes and therapeutic vulnerabilities in CCA may be captured by molecular investigations in bile, where we performed bile proteomic and metabolomic analyses that help discovery yet unknown pathways relevant to human iCCA.

New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

Casadei-Gardini, Andrea;Aldrighetti, Luca;
2022-01-01

Abstract

Cholangiocarcinoma (CCA) is still a deadly tumour. Histological and molecular aspects of thioacetamide (TAA)-induced intrahepatic CCA (iCCA) in rats mimic those of human iCCA. Carcinogenic changes and therapeutic vulnerabilities in CCA may be captured by molecular investigations in bile, where we performed bile proteomic and metabolomic analyses that help discovery yet unknown pathways relevant to human iCCA.
Bile
Cholangiocarcinoma
G9a histone methyl-transferase
Inflammation
Interleukin-6
KRAS
Metabolic reprogramming
Serine-glycine pathway
Animals
Arachnodactyly
Bile Ducts, Intrahepatic
Carcinogenesis
Contracture
Epigenesis, Genetic
ErbB Receptors
Glucose
Glycine
Humans
Interleukin-6
Mice
Phosphoglycerate Dehydrogenase
Proteomics
Proto-Oncogene Proteins p21(ras)
Rats
Serine
Bile Duct Neoplasms
Cholangiocarcinoma
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/132362
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