This retrospective case-control study aimed to compare 30 versus 40 W power of CO2 laser for the therapy of genitourinary syndrome of menopause (GSM). Postmenopausal women with severe intensity of dyspareunia and dryness were eligible to be included in this study. Primary outcomes were dyspareunia and dryness. Secondary outcomes were itching/burning, dysuria, frequency and urgency, Female Sexual Function Index (FSFI), vaginal maturation value (VMV), and Vaginal Health Index Score (VHIS). One laser therapy was applied every month for 3 months. Outcomes were evaluated at baseline and 1 month following the 3rd therapy. Fifty (25 per group) women were included in this study. In the 30-W group, mean improvement of dyspareunia, dryness, itching/ burning, FSFI, VMV, and VHIS was 6.1 +/- 1.7, 6.0 +/- 1.9, 5.9 +/- 2.0, 16.6 +/- 6.7, 29.9 +/- 13.0, and 11.0 +/- 2.9, respectively (within group comparisons all p < 0.001). In the 40-W group, mean improvement of dyspareunia, dryness, itching/burning, FSFI, VMV, and VHIS was 6.1 +/- 1.7, 6.5 +/- 2.0, 5.2 +/- 2.5, 14.8 +/- 7.1, 25.0 +/- 13.4, and 10.5 +/- 4.1, respectively (within-group comparisons, all p <= 0.001). Comparison between 30 and 40 W revealed that mean improvement or presence of all GSM symptoms and clinical signs was not statistically significant different. CO2 laser therapy may improve GSM symptoms and clinical signs. This improvement did not seem to associate to power of 30 or 40 W.

Microablative fractional CO2 laser for the genitourinary syndrome of menopause: power of 30 or 40 W?

Salvatore, Stefano;
2017

Abstract

This retrospective case-control study aimed to compare 30 versus 40 W power of CO2 laser for the therapy of genitourinary syndrome of menopause (GSM). Postmenopausal women with severe intensity of dyspareunia and dryness were eligible to be included in this study. Primary outcomes were dyspareunia and dryness. Secondary outcomes were itching/burning, dysuria, frequency and urgency, Female Sexual Function Index (FSFI), vaginal maturation value (VMV), and Vaginal Health Index Score (VHIS). One laser therapy was applied every month for 3 months. Outcomes were evaluated at baseline and 1 month following the 3rd therapy. Fifty (25 per group) women were included in this study. In the 30-W group, mean improvement of dyspareunia, dryness, itching/ burning, FSFI, VMV, and VHIS was 6.1 +/- 1.7, 6.0 +/- 1.9, 5.9 +/- 2.0, 16.6 +/- 6.7, 29.9 +/- 13.0, and 11.0 +/- 2.9, respectively (within group comparisons all p < 0.001). In the 40-W group, mean improvement of dyspareunia, dryness, itching/burning, FSFI, VMV, and VHIS was 6.1 +/- 1.7, 6.5 +/- 2.0, 5.2 +/- 2.5, 14.8 +/- 7.1, 25.0 +/- 13.4, and 10.5 +/- 4.1, respectively (within-group comparisons, all p <= 0.001). Comparison between 30 and 40 W revealed that mean improvement or presence of all GSM symptoms and clinical signs was not statistically significant different. CO2 laser therapy may improve GSM symptoms and clinical signs. This improvement did not seem to associate to power of 30 or 40 W.
Dryness
Dyspareunia
FSFI
GSM
Laser power
Urgency
Case-Control Studies
Female
Humans
Lasers, Gas
Menopause
Middle Aged
Retrospective Studies
Syndrome
Treatment Outcome
Vaginal Diseases
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/133057
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