The adult brain retains over life endogenous neural stem/precursor cells (eNPCs) within the subventricular zone (SVZ). Whether or not these cells exert physiological functions is still unclear. In the present work, we provide evidence that SVZ-eNPCs tune structural, electrophysiological, and behavioural aspects of striatal function via secretion of insulin-like growth factor binding protein-like 1 (IGFBPL1). In mice, selective ablation of SVZ-eNPCs or selective abrogation of IGFBPL1 determined an impairment of striatal medium spiny neuron morphology, a higher failure rate in GABAergic transmission mediated by fast-spiking interneurons, and striatum-related behavioural dysfunctions. We also found IGFBPL1 expression in the human SVZ, foetal and induced-pluripotent stem cell-derived NPCs. Finally, we found a significant correlation between SVZ damage, reduction of striatum volume, and impairment of information processing speed in neurological patients. Our results highlight the physiological role of adult SVZ-eNPCs in supporting cognitive functions by regulating striatal neuronal activity.

Neural precursor cells tune striatal connectivity through the release of IGFBPL1 / Butti, Erica; Cattaneo, Stefano; Bacigaluppi, Marco; Cambiaghi, Marco; Scotti, Giulia Maria; Brambilla, Elena; Ruffini, Francesca; Sferruzza, Giacomo; Ripamonti, Maddalena; Simeoni, Fabio; Cacciaguerra, Laura; Zanghì, Aurora; Quattrini, Angelo; Fesce, Riccardo; Panina-Bordignon, Paola; Giannese, Francesca; Cittaro, Davide; Kuhlmann, Tanja; D'Adamo, Patrizia; Rocca, Maria Assunta; Taverna, Stefano; Martino, Gianvito. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 13:1(2022). [10.1038/s41467-022-35341-y]

Neural precursor cells tune striatal connectivity through the release of IGFBPL1

Cattaneo, Stefano;Bacigaluppi, Marco;Sferruzza, Giacomo;Ripamonti, Maddalena;Cacciaguerra, Laura;Panina-Bordignon, Paola;D'Adamo, Patrizia;Rocca, Maria Assunta;Martino, Gianvito
2022-01-01

Abstract

The adult brain retains over life endogenous neural stem/precursor cells (eNPCs) within the subventricular zone (SVZ). Whether or not these cells exert physiological functions is still unclear. In the present work, we provide evidence that SVZ-eNPCs tune structural, electrophysiological, and behavioural aspects of striatal function via secretion of insulin-like growth factor binding protein-like 1 (IGFBPL1). In mice, selective ablation of SVZ-eNPCs or selective abrogation of IGFBPL1 determined an impairment of striatal medium spiny neuron morphology, a higher failure rate in GABAergic transmission mediated by fast-spiking interneurons, and striatum-related behavioural dysfunctions. We also found IGFBPL1 expression in the human SVZ, foetal and induced-pluripotent stem cell-derived NPCs. Finally, we found a significant correlation between SVZ damage, reduction of striatum volume, and impairment of information processing speed in neurological patients. Our results highlight the physiological role of adult SVZ-eNPCs in supporting cognitive functions by regulating striatal neuronal activity.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/134391
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