Atezolizumab plus bevacizumab versus lenvatinib for unresectable hepatocellular carcinoma: a large real-life worldwide population

Casadei-Gardini, Andrea; Rimini, Margherita; Tada, Toshifumi; Suda, Goki; Shimose, Shigeo; Kudo, Masatoshi; Cheon, Jaekyung; Finkelmeier, Fabian; Lim, Ho Yeong; Rimassa, Lorenza; Presa, José; Masi, Gianluca; Yoo, Changhoon; Lonardi, Sara; Tovoli, Francesco; Kumada, Takashi; Sakamoto, Naoya; Iwamoto, Hideki; Aoki, Tomoko; Chon, Hong Jae; Himmelsbach, Vera; Pressiani, Tiziana; Montes, Margarida; Vivaldi, Caterina; Soldà, Caterina; Piscaglia, Fabio; Hiraoka, Atsushi; Sho, Takuya; Niizeki, Takashi; Nishida, Naoshi; Steup, Christoph; Iavarone, Massimo; Di Costanzo, Giovanni; Marra, Fabio; Scartozzi, Mario; Tamburini, Emiliano; Cabibbo, Giuseppe; Foschi, Francesco Giuseppe; Silletta, Marianna; Hirooka, Masashi; Kariyama, Kazuya; Tani, Joji; Atsukawa, Masanori; Takaguchi, Koichi; Itobayashi, Ei; Fukunishi, Shinya; Tsuji, Kunihiko; Ishikawa, Toru; Tajiri, Kazuto; Ochi, Hironori; Yasuda, Satoshi; Toyoda, Hidenori; Ogawa, Chikara; Nishimura, Takashi; Hatanaka, Takeshi; Kakizaki, Satoru; Shimada, Noritomo; Kawata, Kazuhito; Tada, Fujimasa; Ohama, Hideko; Nouso, Kazuhiro; Morishita, Asahiro; Tsutsui, Akemi; Nagano, Takuya; Itokawa, Norio; Okubo, Tomomi; Arai, Taeang; Imai, Michitaka; Kosaka, Hisashi; Naganuma, Atsushi; Koizumi, Yohei; Nakamura, Shinichiro; Kaibori, Masaki; Iijima, Hiroko; Hiasa, Yoichi; Burgio, Valentina; Persano, Mara; Della Corte, Angelo; Ratti, Francesca; De Cobelli, Francesco; Aldrighetti, Luca; Cascinu, Stefano; Cucchetti, Alessandro

doi:10.1016/j.ejca.2022.11.017

Atezolizumab plus bevacizumab and lenvatinib have not been compared in a randomised controlled trial. We conducted a retrospective multi-centre study to compare the clinical efficacy and safety of lenvatinib and atezolizumab with bevacizumab as a first-line treatment for patients with unresectable HCC in the real-world scenario.

Atezolizumab plus bevacizumab versus lenvatinib for unresectable hepatocellular carcinoma: a large real-life worldwide population / Casadei-Gardini, Andrea; Rimini, Margherita; Tada, Toshifumi; Suda, Goki; Shimose, Shigeo; Kudo, Masatoshi; Cheon, Jaekyung; Finkelmeier, Fabian; Lim, Ho Yeong; Rimassa, Lorenza; Presa, José; Masi, Gianluca; Yoo, Changhoon; Lonardi, Sara; Tovoli, Francesco; Kumada, Takashi; Sakamoto, Naoya; Iwamoto, Hideki; Aoki, Tomoko; Chon, Hong Jae; Himmelsbach, Vera; Pressiani, Tiziana; Montes, Margarida; Vivaldi, Caterina; Soldà, Caterina; Piscaglia, Fabio; Hiraoka, Atsushi; Sho, Takuya; Niizeki, Takashi; Nishida, Naoshi; Steup, Christoph; Iavarone, Massimo; Di Costanzo, Giovanni; Marra, Fabio; Scartozzi, Mario; Tamburini, Emiliano; Cabibbo, Giuseppe; Foschi, Francesco Giuseppe; Silletta, Marianna; Hirooka, Masashi; Kariyama, Kazuya; Tani, Joji; Atsukawa, Masanori; Takaguchi, Koichi; Itobayashi, Ei; Fukunishi, Shinya; Tsuji, Kunihiko; Ishikawa, Toru; Tajiri, Kazuto; Ochi, Hironori; Yasuda, Satoshi; Toyoda, Hidenori; Ogawa, Chikara; Nishimura, Takashi; Hatanaka, Takeshi; Kakizaki, Satoru; Shimada, Noritomo; Kawata, Kazuhito; Tada, Fujimasa; Ohama, Hideko; Nouso, Kazuhiro; Morishita, Asahiro; Tsutsui, Akemi; Nagano, Takuya; Itokawa, Norio; Okubo, Tomomi; Arai, Taeang; Imai, Michitaka; Kosaka, Hisashi; Naganuma, Atsushi; Koizumi, Yohei; Nakamura, Shinichiro; Kaibori, Masaki; Iijima, Hiroko; Hiasa, Yoichi; Burgio, Valentina; Persano, Mara; Della Corte, Angelo; Ratti, Francesca; De Cobelli, Francesco; Aldrighetti, Luca; Cascinu, Stefano; Cucchetti, Alessandro. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - 180:(2023), pp. 9-20. [10.1016/j.ejca.2022.11.017]