Pathophysiology and effects of endogenous glucocorticoid (GC) excess on skeletal endpoints as well as awareness and management of bone fragility are reviewed. Cushing's syndrome (CS) increase the risk of fracture affecting prevalently bone quality. Bone antiresorptive agents (SERMs, bisphosphonates and denosumab) as well as teriparatide increase bone mineral density and in some instances reduce fracture risk. Awareness and management of bone health in CS can be improved.(c) 2021 Elsevier Ltd. All rights reserved.
Osteopathy in mild adrenal Cushing's syndrome and Cushing disease
Frara, StefanoPrimo
;Allora, Agnese;di Filippo, Luigi;Formenti, Anna Maria;Giustina, Andrea
Ultimo
2021-01-01
Abstract
Pathophysiology and effects of endogenous glucocorticoid (GC) excess on skeletal endpoints as well as awareness and management of bone fragility are reviewed. Cushing's syndrome (CS) increase the risk of fracture affecting prevalently bone quality. Bone antiresorptive agents (SERMs, bisphosphonates and denosumab) as well as teriparatide increase bone mineral density and in some instances reduce fracture risk. Awareness and management of bone health in CS can be improved.(c) 2021 Elsevier Ltd. All rights reserved.File in questo prodotto:
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