: In the past two decades brain connectomics has evolved into a major concept in neuroscience. However, the current perspective on brain connectivity and how it underpins brain function relies mainly on the hemodynamic signal of functional magnetic resonance imaging (MRI). Molecular imaging provides unique information inaccessible to MRI-based and electrophysiological techniques. Thus, positron emission tomography (PET) has been successfully applied to measure neural activity, neurotransmission, and proteinopathies in normal and pathological cognition. Here, we position molecular imaging within the brain connectivity framework from the perspective of timeliness, validity, reproducibility, and resolution. We encourage the neuroscientific community to take an integrative approach whereby MRI-based, electrophysiological techniques, and molecular imaging contribute to our understanding of the brain connectome.

Brain connectomics: time for a molecular imaging perspective? / Sala, Arianna; Lizarraga, Aldana; Caminiti, Silvia Paola; Calhoun, Vince D; Eickhoff, Simon B; Habeck, Christian; Jamadar, Sharna D; Perani, Daniela; Pereira, Joana B; Veronese, Mattia; Yakushev, Igor. - In: TRENDS IN COGNITIVE SCIENCES. - ISSN 1364-6613. - 27:4(2023), pp. 353-366. [10.1016/j.tics.2022.11.015]

Brain connectomics: time for a molecular imaging perspective?

Sala, Arianna
Primo
;
Caminiti, Silvia Paola;Perani, Daniela;
2023-01-01

Abstract

: In the past two decades brain connectomics has evolved into a major concept in neuroscience. However, the current perspective on brain connectivity and how it underpins brain function relies mainly on the hemodynamic signal of functional magnetic resonance imaging (MRI). Molecular imaging provides unique information inaccessible to MRI-based and electrophysiological techniques. Thus, positron emission tomography (PET) has been successfully applied to measure neural activity, neurotransmission, and proteinopathies in normal and pathological cognition. Here, we position molecular imaging within the brain connectivity framework from the perspective of timeliness, validity, reproducibility, and resolution. We encourage the neuroscientific community to take an integrative approach whereby MRI-based, electrophysiological techniques, and molecular imaging contribute to our understanding of the brain connectome.
2023
PET
connectivity
electroencephalography
magnetic resonance imaging
networks
positron emission tomography
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S136466132200300X-main.pdf

solo gestori archivio

Tipologia: PDF editoriale (versione pubblicata dall'editore)
Licenza: Copyright dell'editore
Dimensione 2.5 MB
Formato Adobe PDF
2.5 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/136437
Citazioni
  • ???jsp.display-item.citation.pmc??? 13
  • Scopus 29
  • ???jsp.display-item.citation.isi??? 25
social impact