Introduction. Desmoplastic and neurotropic melanoma is rare and involvement of the subungual skin is an exceptional finding. Observation. We report the second case of desmoplastic and neurotropic subungual melanoma in the literature occurring in a 71-year-old woman. Discussion. In our patient, the histological diagnosis of desmoplastic melanoma was particularly difficult because of the exceptional involvement of the subungual skin. Microscopic neurotropism and immunohistochemical studies were the clues in diagnosing desmoplastic melanoma.
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