HU and IHF proteins have long been considered the prokaryotic analogues of eukaryotic histones. Their ability to bend DNA, however, is distinctly similar to that of eukaryotic HMG-box proteins, a recently identified family of chromatin components and transcription factors. In some conditions, HU and HMG1-like proteins can even be swapped, both in vitro and in vivo. In spite of this, HU/IHF and HMG-box proteins are not evolutionarily related, and represent two independent solutions for the same biochemical problem.
Prokaryotic HU and eukaryotic HMG1: a kinked relationship
Bianchi, M E
1994-01-01
Abstract
HU and IHF proteins have long been considered the prokaryotic analogues of eukaryotic histones. Their ability to bend DNA, however, is distinctly similar to that of eukaryotic HMG-box proteins, a recently identified family of chromatin components and transcription factors. In some conditions, HU and HMG1-like proteins can even be swapped, both in vitro and in vivo. In spite of this, HU/IHF and HMG-box proteins are not evolutionarily related, and represent two independent solutions for the same biochemical problem.File in questo prodotto:
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