: Since early May 2022, some monkeypox virus (MPXV) infections have been reported from countries where the disease is not endemic. Within 2 months, the number of patients has increased extensively, becoming the most considerable MPXV outbreak described. Smallpox vaccines demonstrated high efficacy against MPXVs in the past and are considered a crucial outbreak control measure. However, viruses isolated during the current outbreak carry distinct genetic variations, and the cross-neutralizing capability of antibodies remains to be assessed. Here we report that serum antibodies elicited by first-generation smallpox vaccines can neutralize the current MPXV more than 40 years after vaccine administration.

Smallpox vaccination-elicited antibodies cross-neutralize 2022-Monkeypox virus Clade II / Criscuolo, E.; Giuliani, B.; Ferrarese, R.; Ferrari, D.; Locatelli, M.; Clementi, M.; Mancini, N.; Clementi, N.. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 95:3(2023), p. e28643. [10.1002/jmv.28643]

Smallpox vaccination-elicited antibodies cross-neutralize 2022-Monkeypox virus Clade II

Criscuolo E.
Primo
;
Giuliani B.;Ferrarese R.;Clementi M.;Mancini N.;Clementi N.
Ultimo
2023-01-01

Abstract

: Since early May 2022, some monkeypox virus (MPXV) infections have been reported from countries where the disease is not endemic. Within 2 months, the number of patients has increased extensively, becoming the most considerable MPXV outbreak described. Smallpox vaccines demonstrated high efficacy against MPXVs in the past and are considered a crucial outbreak control measure. However, viruses isolated during the current outbreak carry distinct genetic variations, and the cross-neutralizing capability of antibodies remains to be assessed. Here we report that serum antibodies elicited by first-generation smallpox vaccines can neutralize the current MPXV more than 40 years after vaccine administration.
2023
immunity
monkeypox
neutralizing antibodies
vaccines
vaccinia virus
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/139257
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