OBJECTIVES The aim of this study was to investigate the safety and efficacy of coronary protection by preventive coronary wiring and stenting across the coronary ostia in patients at high risk for coronary obstruction after transcatheter aortic valve replacement (TAVR).BACKGROUND Coronary obstruction following TAVR is a life-threatening complication with high procedural and short-term mortality.METHODS Data were collected retrospectively from a multicenter international registry between April 2011 and February 2019.RESULTS Among 236 patients undergoing coronary protection with preventive coronary wiring, 143 had eventually stents implanted across the coronary ostia after valve deployment. At 3-year follow-up, rates of cardiac death were 7.8% in patients receiving stents and 15.7% in those not receiving stents (adjusted hazard ratio: 0.42; 95% confidence interval: 0.14 to 1.28; p ¼ 0.13). There were 2 definite stent thromboses (0.9%) in patients receiving stents, both occurring after TAVR in “valve-in-valve” procedures. In patients not receiving stents, there were 4 delayed coronary occlusions (DCOs) (4.3%), occurring from 5 min to 6 h after wire removal. Three cases occurred in valve-in-valve procedures and 1 in a native aortic valve procedure. Distance between the virtual transcatheter valve and the protected coronary ostia <4 mm was present in 75.0% of patients with DCO compared with 30.4% of patients without DCO (p ¼ 0.19).CONCLUSIONS In patients undergoing TAVR at high risk for coronary obstruction, preventive stent implantation across the coronary ostia is associated with good mid-term survival rates and low rates of stent thrombosis. Patients undergoing coronary protection with wire only have a considerable risk for DCO. (J Am Coll Cardiol Intv 2020;13:739–47)

Coronary Protection to Prevent Coronary Obstruction During TAVR / Palmerini, Tullio; Chakravarty, Tarun; Saia, Francesco; Bruno Antonio, G.; Bacchi-Reggiani, Maria-Letizia; Marrozzini, Cinzia; Patel, Chinar; Patel, Vivek; Testa, Luca; Bedogni, Francesco; Ancona, Marco; Montorfano, M; Chieffo, Alaide; Olivares, Paolo; Bartorelli Antonio, L.; Buscaglia, Angelo; Porto, Italo; Nickenig, Georg; Grube, Eberhard; Sinning, Jan-Malte; De Carlo, Marco; Petronio Anna, Sonia; Barbanti, Marco; Tamburino, Corrado; Iadanza, Alessandro; Burzotta, Francesco; Trani, Carlo; Fraccaro, Chiara; Tarantini, Giuseppe; Aranzulla Tiziana, C.; De Benedictis, Mauro; Pagnotta, Paolo; Stefanini Giulio, G.; Miura, Mizuki; Taramasso, Maurizio; Kang, Jee-Hoon; Kim, Hyo-Soo; Codner, Pablo; Kornowski, Ran; Pelliccia, Francesco; Vignali, Luigi; Taglieri, Nevio; Ghetti, Gabriele; Leone, Alessandro; Galiè, Nazzareno; Makkar, Raj. - In: JACC: CARDIOVASCULAR INTERVENTIONS. - ISSN 1936-8798. - 13:6(2020), pp. 739-747. [10.1016/j.jcin.2019.11.024]

Coronary Protection to Prevent Coronary Obstruction During TAVR

Montorfano M;Chieffo Alaide;
2020-01-01

Abstract

OBJECTIVES The aim of this study was to investigate the safety and efficacy of coronary protection by preventive coronary wiring and stenting across the coronary ostia in patients at high risk for coronary obstruction after transcatheter aortic valve replacement (TAVR).BACKGROUND Coronary obstruction following TAVR is a life-threatening complication with high procedural and short-term mortality.METHODS Data were collected retrospectively from a multicenter international registry between April 2011 and February 2019.RESULTS Among 236 patients undergoing coronary protection with preventive coronary wiring, 143 had eventually stents implanted across the coronary ostia after valve deployment. At 3-year follow-up, rates of cardiac death were 7.8% in patients receiving stents and 15.7% in those not receiving stents (adjusted hazard ratio: 0.42; 95% confidence interval: 0.14 to 1.28; p ¼ 0.13). There were 2 definite stent thromboses (0.9%) in patients receiving stents, both occurring after TAVR in “valve-in-valve” procedures. In patients not receiving stents, there were 4 delayed coronary occlusions (DCOs) (4.3%), occurring from 5 min to 6 h after wire removal. Three cases occurred in valve-in-valve procedures and 1 in a native aortic valve procedure. Distance between the virtual transcatheter valve and the protected coronary ostia <4 mm was present in 75.0% of patients with DCO compared with 30.4% of patients without DCO (p ¼ 0.19).CONCLUSIONS In patients undergoing TAVR at high risk for coronary obstruction, preventive stent implantation across the coronary ostia is associated with good mid-term survival rates and low rates of stent thrombosis. Patients undergoing coronary protection with wire only have a considerable risk for DCO. (J Am Coll Cardiol Intv 2020;13:739–47)
2020
coronary obstruction, stent, thrombosis, transcatheter aortic valve replacement
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/143041
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