OBJECTIVE: We evaluated the impact of post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) in a prospective study.METHODS: This was a single-center, prospective registry of patients undergoing PCI following a baseline FFR ≤0.80. Patients were divided according to the post-PCI FFR value (<0.90 vs ≥0.90). The primary endpoint was the proportion of cases in which further action was undertaken in light of a post-PCI FFR value <0.90.RESULTS: Of 65 PCIs, a total of 43 (66%) had a post-PCI FFR <0.90 and 22 (34%) had a post-PCI FFR ≥0.90. Baseline characteristics were similar between groups. Baseline FFR was similar between patients with post-PCI FFR <0.90 and ≥0.90 (0.72 ± 0.08 vs 0.69 ± 0.14; P=.40). Post-PCI FFR values were 0.82 ± 0.05 in post-PCI FFR <0.90 patients and 0.94 ± 0.02 in post-PCI FFR ≥0.90 patients (P<.001). The most common reason for a post-PCI <0.90 was residual small-vessel disease (42%). In 15 patients (35%) with a post-PCI FFR <0.90, an action was undertaken. An increase of 0.05 ± 0.07 in FFR value (P=.01) was noted after these maneuvers. However, a final FFR value ≥0.90 was achieved in only 3 patients (20%). The major adverse cardiac event (MACE) rate at 1-year follow-up was higher in patients with final FFR <0.90 (31.6% vs 9.1%; P=.047).CONCLUSIONS: A suboptimal physiologic outcome is observed in two-thirds of patients undergoing PCI. Despite further interventions, a satisfactory outcome is achieved in only a minority of cases. A post-PCI suboptimal physiologic outcome appears to be associated with a higher incidence of MACE at follow-up.
Impact of Post-Percutaneous Coronary Intervention Fractional Flow Reserve Measurement on Procedural Management and Clinical Outcomes: The REPEAT-FFR Study / Azzalini, Lorenzo; Poletti, Enrico; Demir Ozan, M.; Ancona Marco, B.; Mangieri, Antonio; Giannini, Francesco; Carlino, Mauro; Chieffo, Alaide; Montorfano, M; Colombo, Antonio; Latib, Azeem. - In: THE JOURNAL OF INVASIVE CARDIOLOGY. - ISSN 1557-2501. - 31:8(2019), pp. 229-234.