Background and purpose: The differences in cognitive function between primary progressive and secondary progressive multiple sclerosis (MS) remain unclear. We compared cognitive performance between primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS), and explored the structural and functional magnetic resonance imaging (MRI) correlates of their cognitive functions. Methods: Seventy-five healthy controls and 183 MS patients (60 PPMS and 123 SPMS) underwent 3.0-T MRI. MS patients were administered the Brief Repeatable Battery of Neuropsychological Tests; cognitive domain z-scores were calculated and then averaged to obtain a measure of global cognition. Using hierarchical linear regression analysis, the contribution of lesion volumes, normalized brain volumes, white matter (WM) fractional anisotropy (FA) and mean diffusivity abnormalities, and resting state (RS) functional connectivity (FC) alterations to global cognition in PPMS and SPMS was investigated. Results: PPMS and SPMS had similar z-scores in all investigated cognitive domains. Poor global cognitive function was associated with decreased FA of the medial lemniscus (ΔR2  = 0.11, p = 0.011) and lower normalized gray matter volume (ΔR2  = 0.29, p < 0.001) in PPMS, and with decreased FA of the fornix (ΔR2  = 0.35, p < 0.001) and lower normalized WM volume (ΔR2  = 0.05; p = 0.034) in SPMS. Conclusions: PPMS and SPMS had similar neuropsychological performance. Cognitive dysfunction in PPMS and SPMS was related to distinct patterns of structural MRI abnormalities and involvement of different WM tracts, whereas RS FC alterations did not contribute to explaining their global cognitive functioning.

Cognitive function in primary and secondary progressive multiple sclerosis: A multiparametric magnetic resonance imaging study / Mistri, Damiano; Cacciaguerra, Laura; Valsasina, Paola; Pagani, Elisabetta; Filippi, Massimo; Rocca, Maria A. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - 30:9(2023), pp. 2801-2810. [10.1111/ene.15900]

Cognitive function in primary and secondary progressive multiple sclerosis: A multiparametric magnetic resonance imaging study

Mistri, Damiano
Primo
;
Cacciaguerra, Laura
Secondo
;
Filippi, Massimo
Penultimo
;
Rocca, Maria A
Ultimo
2023-01-01

Abstract

Background and purpose: The differences in cognitive function between primary progressive and secondary progressive multiple sclerosis (MS) remain unclear. We compared cognitive performance between primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS), and explored the structural and functional magnetic resonance imaging (MRI) correlates of their cognitive functions. Methods: Seventy-five healthy controls and 183 MS patients (60 PPMS and 123 SPMS) underwent 3.0-T MRI. MS patients were administered the Brief Repeatable Battery of Neuropsychological Tests; cognitive domain z-scores were calculated and then averaged to obtain a measure of global cognition. Using hierarchical linear regression analysis, the contribution of lesion volumes, normalized brain volumes, white matter (WM) fractional anisotropy (FA) and mean diffusivity abnormalities, and resting state (RS) functional connectivity (FC) alterations to global cognition in PPMS and SPMS was investigated. Results: PPMS and SPMS had similar z-scores in all investigated cognitive domains. Poor global cognitive function was associated with decreased FA of the medial lemniscus (ΔR2  = 0.11, p = 0.011) and lower normalized gray matter volume (ΔR2  = 0.29, p < 0.001) in PPMS, and with decreased FA of the fornix (ΔR2  = 0.35, p < 0.001) and lower normalized WM volume (ΔR2  = 0.05; p = 0.034) in SPMS. Conclusions: PPMS and SPMS had similar neuropsychological performance. Cognitive dysfunction in PPMS and SPMS was related to distinct patterns of structural MRI abnormalities and involvement of different WM tracts, whereas RS FC alterations did not contribute to explaining their global cognitive functioning.
2023
MRI
executive function
memory
multiple sclerosis
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/143576
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