We have identified in plasma cells a novel ATG5-dependent selective negative control on the secretory pathway, which restricts antibody production, sustaining energy metabolism. Revealing new immune functions, autophagy is required in vivo for antibody responses and to maintain the memory plasma cell compartment.
The role of autophagy in plasma cell ontogenesis / Pengo, N; Cenci, S. - In: AUTOPHAGY. - ISSN 1554-8627. - 9:6(2013), pp. 942-944. [10.4161/auto.24399]
The role of autophagy in plasma cell ontogenesis
Cenci S
Ultimo
2013-01-01
Abstract
We have identified in plasma cells a novel ATG5-dependent selective negative control on the secretory pathway, which restricts antibody production, sustaining energy metabolism. Revealing new immune functions, autophagy is required in vivo for antibody responses and to maintain the memory plasma cell compartment.File in questo prodotto:
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