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Impact of lymphnode ratio and number of lymphnode metastases on survival and recurrence in laryngeal squamous carcinoma / Molteni, G., Nocini, R., Mattiolo, F., Nakayama, M., Dedivitis, R., Mannelli, G., Crosetti, E., Chiesa -Estomba, C., Sistiaga-Suarez, J., Giordano, L., Galli, A., Lionello, M., Mercante, G., Ralli, M., Fermi, M., Rodriguez-Klein, A., Mayo, M., Serafini, E., Pirola, F., Paderno, A., et al.. - In: HEAD & NECK. - ISSN 1043-3074. - 45:9(2023), pp. 2274-2293. [10.1002/hed.27471]

Impact of lymphnode ratio and number of lymphnode metastases on survival and recurrence in laryngeal squamous carcinoma

Molteni G.
Primo
;Giordano L.;Galli A.;Rossi G.;Bussi M.;
2023-01-01
2023
Introduction: The aim of this study is to assess the impact of lymph node ratio (LNR) and number of positive lymph nodes (NPLN) on mortality and recurrence rates in patients with laryngeal squamous cell carcinoma. Materials and methods: We conducted a retrospective multicenter international study involving 24 Otorhinolaryngology-Head and Neck Surgery divisions. Disease-specific survival (DSS) and disease-free survival (DFS) were evaluated as the main outcomes. The curves for DSS and DFS according to NPLN and LNR were analyzed to identify significant variations and establish specific cut-off values. Results: 2507 patients met the inclusion criteria. DSS and DFS were significantly different in the groups of patients stratified according to LNR and NPLN. The 5-year DSS and DFS based on LNR and NPLN demonstrated an improved ability to stratify patients when compared to pN staging. Conclusion: Our data demonstrate the potential prognostic value of NPLN and LNR in laryngeal squamous cell carcinoma
laryngeal cancer; lymph node; lymph node metastasis; lymph node ratio; oncology
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/148017
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