Age-related macular degeneration (AMD) is a complex and multifactorial disease characterized by the damage of the unit comprised of the photoreceptors, retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris. Although the outer retina appears to be mainly affected in this disorder, several evidences exhibit that also the inner retina may be impaired. In this review we will provide a description of the prominent histologic and imaging findings suggesting an inner retinal loss in these eyes. In details, structural optical coherence tomography (OCT) technology proved either the inner and outer retina is impacted by AMD and that these two impairments are associated. Therefore, the purpose of this review is to provide a description of the role of neurodegeneration in AMD in order to better understand the relationship between neuronal loss and the outer retinal damage in this disease.

Retinal neurodegeneration in age-related macular degeneration / Barresi, Costanza; Chhablani, Jay; Dolz-Marco, Rosa; Gallego-Pinazo, Robero; Berni, Alessandro; Bandello, Francesco; Borrelli, Enrico. - In: EUROPEAN JOURNAL OF OPHTHALMOLOGY. - ISSN 1724-6016. - (2023), p. 11206721231186166. [10.1177/11206721231186166]

Retinal neurodegeneration in age-related macular degeneration

Barresi, Costanza
Primo
;
Berni, Alessandro;Bandello, Francesco
Penultimo
;
Borrelli, Enrico
Ultimo
2023-01-01

Abstract

Age-related macular degeneration (AMD) is a complex and multifactorial disease characterized by the damage of the unit comprised of the photoreceptors, retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris. Although the outer retina appears to be mainly affected in this disorder, several evidences exhibit that also the inner retina may be impaired. In this review we will provide a description of the prominent histologic and imaging findings suggesting an inner retinal loss in these eyes. In details, structural optical coherence tomography (OCT) technology proved either the inner and outer retina is impacted by AMD and that these two impairments are associated. Therefore, the purpose of this review is to provide a description of the role of neurodegeneration in AMD in order to better understand the relationship between neuronal loss and the outer retinal damage in this disease.
2023
Age-Related macular degeneration
CORNEA/EXTERNAL DISEASE
RETINA
examination
inner retinal/Vitreoretinal dystrophies
retinal pathology / research
techniques
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/148801
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