Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3.4 cm arterialized hepatic lesion and a 7 cm paraduodenal mass. Surgical resection of both lesions and histological examination revealed an inflammatory hepatocellular adenoma and a unicentric plasma cell type of Castleman disease. Moreover, a diffuse AA amyloid deposition in the liver was observed. Resection of both lesions was associated with an improvement of the symptoms. To our knowledge, this is the first report of a synchronous presentation of a unicentric plasma cell type of Castleman disease, inflammatory hepatocellular adenoma and AA amyloidosis.

Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report / De Vito, C; Papathomas, G T; Pedica, F; Kane, P; Amir, A; Heaton, N; Quaglia, A.. - In: ANNALS OF HEPATOLOGY. - ISSN 1665-2681. - 18:1(2019), pp. 263-268. [10.5604/01.3001.0012.7936]

Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report

Pedica F;
2019-01-01

Abstract

Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3.4 cm arterialized hepatic lesion and a 7 cm paraduodenal mass. Surgical resection of both lesions and histological examination revealed an inflammatory hepatocellular adenoma and a unicentric plasma cell type of Castleman disease. Moreover, a diffuse AA amyloid deposition in the liver was observed. Resection of both lesions was associated with an improvement of the symptoms. To our knowledge, this is the first report of a synchronous presentation of a unicentric plasma cell type of Castleman disease, inflammatory hepatocellular adenoma and AA amyloidosis.
2019
Hepatocellular adenoma, Unicentric plasma cell type, Castleman disease, Amyloidosis, Systemic symptoms, Interleukin-6
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/149604
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