About 10% of pancreatic cancer patients are aged ≤50 at diagnosis and defined as Early Onset Pancreatic Cancer (EOPC). There is limited information regarding risk factors for EOPC occurrence and their outcome.To investigate risk factors, presentation features and outcome of EOPC patients.Consecutive, histologically confirmed, pancreatic cancer patients enrolled. Data regarding environmental and genetic risk factors, clinical and pathological information, treatment and survival were recorded. EOPC patients (aged ≤50 at diagnosis) were compared to older subjects.Twenty-five of 293 patients (8.5%) had EOPC. There was no difference regarding sex distribution, medical conditions and alcohol intake between EOPC and older subjects. EOPC patients were more frequently current smokers (56% vs 28% p = 0.001) and started smoking at a significantly lower mean age (19.8 years, 95%CI 16.7-22.9) as compared to older patients (26.1, 95%CI 24.2-28) (p = 0.001). Current smoking (OR 7.5; 95%CI 1.8-30; p = 0.004) and age at smoking initiation (OR 0.8 for every increasing year; 95%CI 0.7-0.9; p = 0.01) were significant and independent risk factors for diagnosis of EOPC. There were no differences regarding genetic syndromes and pancreatic cancer family history. EOCP presented less frequently with jaundice (16% vs 44%, p = 0.006) and had a higher rate of unresectable disease, albeit not significantly (84% vs 68%, p = 0.1). EOPC patients were more frequently fit for surgery or chemotherapy than their counterpart, resulting in similar stage-specific survival probability.EOPC seems related to active and early smoking but not to familial syndromes. Young patients display aggressive disease but not worse outcome.

Early onset pancreatic cancer. Risk factors, presentation and outcome / Piciucchi, Matteo; Valente, Roberto; LA TORRE, Marco; Cavallini, Marco; G., Costamagna; Ziparo, Vincenzo; DELLE FAVE, Gianfranco; Capurso, Gabriele; Larghi, Alberto; Archibugi, Livia; Signoretti, Marianna; Stigliano, Serena; Zerboni, Giulia; Barucca, Viola; Marchetti, Paolo. - In: PANCREATOLOGY. - ISSN 1424-3903. - 15:2(2015), pp. 151-155. [10.1016/j.pan.2015.01.013]

Early onset pancreatic cancer. Risk factors, presentation and outcome

CAPURSO, Gabriele;ARCHIBUGI, LIVIA;
2015-01-01

Abstract

About 10% of pancreatic cancer patients are aged ≤50 at diagnosis and defined as Early Onset Pancreatic Cancer (EOPC). There is limited information regarding risk factors for EOPC occurrence and their outcome.To investigate risk factors, presentation features and outcome of EOPC patients.Consecutive, histologically confirmed, pancreatic cancer patients enrolled. Data regarding environmental and genetic risk factors, clinical and pathological information, treatment and survival were recorded. EOPC patients (aged ≤50 at diagnosis) were compared to older subjects.Twenty-five of 293 patients (8.5%) had EOPC. There was no difference regarding sex distribution, medical conditions and alcohol intake between EOPC and older subjects. EOPC patients were more frequently current smokers (56% vs 28% p = 0.001) and started smoking at a significantly lower mean age (19.8 years, 95%CI 16.7-22.9) as compared to older patients (26.1, 95%CI 24.2-28) (p = 0.001). Current smoking (OR 7.5; 95%CI 1.8-30; p = 0.004) and age at smoking initiation (OR 0.8 for every increasing year; 95%CI 0.7-0.9; p = 0.01) were significant and independent risk factors for diagnosis of EOPC. There were no differences regarding genetic syndromes and pancreatic cancer family history. EOCP presented less frequently with jaundice (16% vs 44%, p = 0.006) and had a higher rate of unresectable disease, albeit not significantly (84% vs 68%, p = 0.1). EOPC patients were more frequently fit for surgery or chemotherapy than their counterpart, resulting in similar stage-specific survival probability.EOPC seems related to active and early smoking but not to familial syndromes. Young patients display aggressive disease but not worse outcome.
2015
early onset
family history
metastasis
pancreatic cancer
smoking
survival
adolescent
age of onset
aged
delayed diagnosis
female
humans
male
middle aged
neoplasm metastasis
pancreatic neoplasms
risk factors
smoking
survival analysis
treatment outcome
young adult
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/151824
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